Upgrades for the University of Michigan Center for Structural Biology

描述(申请人提供)：密歇根大学结构生物学中心支持两个X射线设备，包括两个Rigaku旋转阳极，每个都配备一个R-Axis IV成像板探测器和一个额外的Bruker Smart2000 CCD相机。然而，这些系统的聚焦光学系统已经过时，一系列其他部件需要升级，以便为大量主要用户、他们的当地合作者和中心的普通用户提供极大的增强服务。这项建议的主要目标是提供增强的但可持续的仪器，大大改善现场数据收集，不仅解决更常规的结晶学问题，而且使我们能够处理和筛选为我们实验室正在研究的日益复杂和大型的蛋白质组件生产的小的、非理想的晶体。

DESCRIPTION (provided by applicant): The Center for Structural Biology at the University of Michigan supports two X-ray facilities, consisting in total of two Rigaku rotating anodes, each equipped with a R-Axis IV imaging plate detector and one with an additional Bruker Smart2000 CCD camera. However, the focusing optics for these systems are antiquated, and a series of other components are in need of upgrades to provide greatly enhanced service to the large number of major users, their local collaborators and the general users of the Center. The major goal of this proposal is to provide enhanced yet sustainable instrumentation that will greatly improve data collection on site for not only more routine crystallographic problems, but also enable us to work with and screen small, non-ideal crystals being produced for the increasingly complex and large protein assemblies being investigated by our labs.