3T MRI Scanner for High Resolution MRI/MRS Research

描述（由申请人提供）：本提案旨在促进芝加哥大学（U of C）购买用于基础和应用研究的3T MRI扫描仪。这种最先进的MRI扫描仪将在信噪比、成像速度和空间分辨率方面对我们目前的设备进行重大改进，并将增加全身成像能力。这种研究专用扫描仪对于保持加州大学生物医学研究的高质量至关重要，也是迫切需要的。3T MRI扫描仪将作为加州大学生物科学系内成像核心设施的一部分，作为全校范围的资源。3T MRI扫描仪的操作和技术支持所需的空间和大量基础设施已经到位。购买，翻新空间和安装3T MRI扫描仪的总成本约为367万美元。除了从这一提案中要求的200万美元外，生物科学系主任和普利兹克医学院已承诺提供资金，以支付与此次采购相关的剩余费用。我们的成像核心的使命是促进非侵入性成像技术的发展和协同应用到广泛的医学研究学科。成像核心的组织、人员配备、设备采购和运营资金都是为了确保这一使命的成功。目前，Imaging Core共支持20个活跃的NIH项目（1个PO 1，1个P50，14个RO 1和4个R21），总价值约为3900万美元。所有这些项目都广泛使用磁共振成像。此外，更多的成像研究NIH RO1和其他拨款提案正在等待。这种最先进的MRI扫描仪将提供最新的3T技术，这对于成功执行和扩展NIH资助的尖端成像研究项目至关重要。

DESCRIPTION (provided by applicant): The purpose of this proposal is to facilitate the purchase of a 3T MRI scanner for basic and applied research at The University of Chicago (U of C). This state-of-the-art MRI scanner will provide significant improvements over our current equipment in signal-to-noise ratio, imaging speed, and spatial resolution, and will add whole body imaging capability. This research-dedicated scanner is critical and urgently needed for maintaining the high quality of biomedical research at the U of C. The 3T MRI scanner will be utilized as a University-wide resource as part of an Imaging Core Facility housed within the Biological Science Division of the U of C. Space and substantial infrastructure for operations and technical support for the 3T MRI scanner are already in place. The total cost for purchasing, renovation of the space, and installation of a 3T MRI scanner is approximately $3.67M. Besides the requested $2M from this proposal, the Dean of the Division of Biological Sciences and the Pritzker School of Medicine has committed the funds to cover the remaining cost associated with this purchase. The mission of our Imaging Core is to promote the development and synergistic application of non- invasive imaging techniques to a broad range of medical research disciplines. The organization, staffing, equipment procurement, and operational funding of the Imaging Core are all designed to assure the success of this mission. Presently, the Imaging Core supports a total of 20 active NIH projects (1 PO1, 1 P50, 14 RO1, and 4 R21) that total ~ $39M. All these projects extensively utilize magnetic resonance imaging. In addition, more imaging research NIH RO1 and other grant proposals are pending. This state-of-the-art MRI scanner will provide the latest 3T technology that is essential for successfully performing and expanding NIH-funded cutting-edge imaging research programs at our institution.