Families of cohort survivors over 90 - Study Center

描述（由申请人提供）：我们建议招募心血管健康研究（CHS）中长期存活者的家庭，用于家庭异常存活的多中心研究（ESF）。CHS队列（n=5888）最初是从1989-90年美国4个社区的医疗保险登记者随机样本中招募的。它们在健康和功能方面已经得到了很好的表征，随着时间的推移，提供了检查许多特定和复合表型的机会。所有人都有储存的DNA或冷冻保存的白色血细胞。我们已经确定，大约有400名90岁及以上的人将在社区卫生服务中提供服务，其中大约200人没有残疾，100人有相当大的家庭（平均12人），包括兄弟姐妹及其子女。我们建议在几个详细层次上描述这些家庭成员的特征，包括例外生存问题工作组建议的最低限度数据集。由于为最小数据集提出的残疾措施可能还没有在儿童中表达，我们还提出了一些措施， 作为衰老和亚临床疾病过程的标志物，在年龄范围内提供信息。我们在大型多中心研究方面有着悠久的合作历史，可以为通用方案和分析方法的设计做出贡献。我们的目标是作为研究中心参与本研究的设计和实施。我们将招募和检查年龄达到90岁的老年人，他们的兄弟姐妹和指数一代的孩子（指数病例和兄弟姐妹）。我们将确定几个潜在的重要异常生存表型的聚类程度。我们可以提供有关环境和行为决定因素以及中间表型的数据，这些数据可以在年轻的老年人中进行评估，并将测量这些家庭的核心表型特征和重要的环境暴露。我们将参与选定性状的聚合和性状组合的评价，为未来的研究提供信息。我们建议首先确定是否“例外生存”是更常见的家庭比预期的，然后将使用组合技术（主成分分析和谱系判别分析），以产生遗传分析的定量表型。

DESCRIPTION (provided by applicant): We propose to recruit families of the long term survivors in the Cardiovascular Health Study (CHS) for the Multicenter Study on Exceptional Survival in Families (ESF). The CHS cohort (n=5888) was originally recruited from a random sample of Medicare enrollees in 4 US communities in 1989-90. They have been extremely well characterized regarding health and function, providing an opportunity to examine many specific as well as composite phenotypes over time. All have stored DNA or cryopreserved white blood cells. We have determined that about 400 individuals aged 90 and over will be available in CHS, with about 200 remaining free of disability and 100 with fairly large families (average 12) including sibs and their children. We would propose to characterize these family members at several levels of detail, to include the minimal data set suggested by the working group on exceptional survival. Since the disability measures proposed for the minimal data set may well not yet be expressed in the children, we also propose measures that would be informative across a spectrum of age as markers of aging and subclinical disease processes. We have a long history of productive collaboration on large multicenter studies and can contribute to the design of common protocols and analytic approaches. Our goal is to contribute as a study center in the design and implementation of this study. We will recruit and examine older adults who have reached age 90, their siblings and the children of the index generation (index cases and siblings). We will determine the extent of clustering of several potential important exceptional survival phenotype. We can contribute data on environmental and behavioral determinants and intermediate phenotypes that can be assessed in younger old adults and will measure core phenotypic characteristics and important environmental exposures in these families. We will participate in the evaluation of aggregation of selected traits and combination of traits to inform future studies. We would propose first determining whether "exceptional survival" is more common in families than expected and then would use combinatorial techniques (principal component analysis and pedigree discriminant analysis) to produce quantitative phenotypes for genetic analysis.