Impact of Exercise on Body Composition in Premature Infants: New Approaches

运动对早产儿身体成分的影响:新方法

基本信息

  • 批准号:
    9194487
  • 负责人:
  • 金额:
    $ 17.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-02-15 至 2017-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): This research consists of a novel intervention designed to increase physical activity of premature babies in their first year of life. The potential beneficial impact of augmented physical activity on 1) body composition, 2) associated biochemical and cellular mechanisms of growth and inflammation, and 3) quality of maternal care will be measured. Premature birth is recognized as the single most important health problem in maternal- child health in the US. Paradoxically, both failure to thrive and obesity are now known to be associated with prematurity, as are osteopenia and increased risk of fracture, and increased risk of cardiovascular disease later in life. We lack cohesive approaches to mitigate these profound threats to health. Despite promising new research demonstrating that physical activity can stimulate the growth of muscle and bone even during intrauterine life (perhaps through metabolic programming), there have been very few attempts to implement and study physical activity interventions in the premature baby. The challenges are substantial and include: measuring body composition; assessing physical activity; engaging caregivers as partners in the intervention; identifying plausible and testable biological mechanisms; and designing interventions that actually increase physical activity and match the rapid pace of motor development early in life. This team of investigators has addressed these challenges. A developmentally dynamic physical activity intervention has been designed and pilot tested-one that engages the caregiver as a partner. Using techniques and tools as far-ranging as DXA, smartphones, doubly labeled water, and lightweight, wireless accelerometers developed specifically for this purpose, the working hypothesis is that the one-year intervention will augment lean body mass (primary outcome variable) and improve bone mineralization and the ratio of lean to fat tissue (secondary outcome variables). The study will gauge the impact of the physical activity intervention on the balance between circulating anabolic mediators (insulin-like growth factor-I and growth hormone binding protein) and inflammation-associated cytokines (interleukin-6, and interleukin-1 receptor antagonist), which antagonize muscle and bone growth. We will additionally: 1) begin to explore how physical activity influences circulating endothelial progenitor cells, which are increasingly viewed as markers of vascular health very early in life, and 2) take advantage of this prospective, interventional study to explore potential genetic determinants of growth in babies born prematurely. Finally, any study involving the premature infant and the data associated with it must be viewed in light of the critical relationship between the mother and baby. The potential broad impact of early life interventions has been recently demonstrated by the success of the "Back-To-Sleep" campaign in mitigating sudden infant death syndrome. Should the positive effects of augmented exercise on body composition be supported, we would then anticipate widespread benefit in preventing long-term health consequences of prematurity at relatively low cost.
描述(由申请人提供):这项研究包括一项新颖的干预措施,旨在增加早产儿第一年的体力活动。将测量增强体力活动对 1) 身体成分、2) 相关的生长和炎症的生化和细胞机制以及 3) 孕产妇护理质量的潜在有益影响。早产被认为是美国母婴健康中最重要的健康问题。矛盾的是,现在已知发育迟缓和肥胖都与早产有关,骨质减少和骨折风险增加以及晚年心血管​​疾病风险增加也是如此。我们缺乏一致的方法来减轻这些对健康的深刻威胁。尽管有希望的新研究表明,即使在子宫内,体力活动也可以刺激肌肉和骨骼的生长(可能通过代谢编程),但很少有人尝试对早产儿实施和研究体力活动干预措施。挑战是巨大的,包括:测量身体成分;评估体力活动;让护理人员作为干预措施的合作伙伴;确定合理且可测试的生物机制;设计干预措施,切实增加体力活动,并与生命早期运动发展的快速步伐相匹配。该研究小组已经解决了这些挑战。一种发展动态的身体活动干预措施已经设计并进行了试点测试,该干预措施让护理人员成为合作伙伴。使用 DXA、智能手机、双标记水和专门为此目的开发的轻型无线加速度计等广泛的技术和工具,工作假设是一年的干预将增加去脂体重(主要结果变量)并改善骨矿化和瘦肉与脂肪组织的比率(次要结果变量)。该研究将评估体力活动干预对循环合成代谢介质(胰岛素样生长因子-I 和生长激素结合蛋白)和炎症相关细胞因子(白细胞介素 6 和白细胞介素 1 受体拮抗剂)之间平衡的影响,这些细胞因子会拮抗肌肉和骨骼的生长。此外,我们还将:1)开始探索体力活动如何影响循环内皮祖细胞,这些细胞越来越多地被视为生命早期血管健康的标志,2)利用这项前瞻性、介入性研究来探索早产儿生长的潜在遗传决定因素。最后,任何涉及早产儿的研究及其相关数据都必须根据母亲和婴儿之间的关键关系来看待。最近“重返睡眠”运动在减轻婴儿猝死综合症方面的成功证明了早期生命干预的潜在广泛影响。如果强化运动对身体成分的积极影响得到支持,我们就可以预期以相对较低的成本预防早产的长期健康后果会产生广泛的益处。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Enhancing the Construct and Content Validity of Rating Scales for Clinical Research: Using Qualitative Methods to Develop a Rating Scale to Assess Parental Perceptions of Their Role in Promoting Infant Exercise.
增强临床研究评价量表的结构和内容有效性:使用定性方法开发评价量表来评估父母对其在促进婴儿运动中的作用的看法。
The Societal Importance of Embracing Counterintuitive Thought in Science: Assisted Exercise in Preterm Infants for Long-term Health Outcomes.
拥抱科学中反直觉思想的社会重要性:早产儿辅助运动以实现长期健康结果。
Feasibility of a caregiver-assisted exercise program for preterm infants.
早产儿护理人员协助锻炼计划的可行性。
  • DOI:
    10.1097/jpn.0b013e31828b244a
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    0
  • 作者:
    McQueen,Dana;Lakes,Kimberley;Rich,Julia;Vaughan,Jessica;Hayes,Gillian;Cooper,Dan;Olshansky,Ellen
  • 通讯作者:
    Olshansky,Ellen
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

DAN M COOPER其他文献

DAN M COOPER的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('DAN M COOPER', 18)}}的其他基金

Supplement Proposal-A Pediatric Clinical Center for Molecular Transducers of Physical Activity (MoTrPAC): Towards a Molecular Map of Exercise in the Pediatric Origins of Health Across the Lifespan
补充提案-体力活动分子传感器儿科临床中心 (MoTrPAC):构建儿科全生命周期健康起源的运动分子图谱
  • 批准号:
    10894540
  • 财政年份:
    2023
  • 资助金额:
    $ 17.5万
  • 项目类别:
UC Irvine CTSA Quality Assurance Supplement
加州大学欧文分校 CTSA 质量保证补充材料
  • 批准号:
    10261888
  • 财政年份:
    2021
  • 资助金额:
    $ 17.5万
  • 项目类别:
THE SEARCH FOR COVID-19 PREVENTION AND CURE: ADDRESSING THE CRITICAL ROLE OF INNATE/ADAPTIVE IMMUNITY BY INTEGRATING NOVEL INFORMATICS, TRANSLATIONAL TECHNOLOGIES, AND ONGOING CLINICAL TRIAL RESEARCH
寻找 COVID-19 的预防和治疗:通过整合新颖的信息学、翻译技术和正在进行的临床试验研究来解决先天/适应性免疫的关键作用
  • 批准号:
    10158982
  • 财政年份:
    2020
  • 资助金额:
    $ 17.5万
  • 项目类别:
Transforming Exercise Testing and Physical Activity Assessment in Children: New Approaches to Advance Clinical Translational Research in Child Health
改变儿童运动测试和体力活动评估:推进儿童健康临床转化研究的新方法
  • 批准号:
    10450177
  • 财政年份:
    2018
  • 资助金额:
    $ 17.5万
  • 项目类别:
Transforming Exercise Testing and Physical Activity Assessment in Children: New Approaches to Advance Clinical Translational Research in Child Health
改变儿童运动测试和体力活动评估:推进儿童健康临床转化研究的新方法
  • 批准号:
    10006855
  • 财政年份:
    2018
  • 资助金额:
    $ 17.5万
  • 项目类别:
Transforming Exercise Testing and Physical Activity Assessment in Children: New Approaches to Advance Clinical Translational Research in Child Health
改变儿童运动测试和体力活动评估:推进儿童健康临床转化研究的新方法
  • 批准号:
    10251868
  • 财政年份:
    2018
  • 资助金额:
    $ 17.5万
  • 项目类别:
A Pediatric Clinical Center for Molecular Transducers of Physical Activity (MoTrPAC): Towards a Molecular Map of Exercise in the Pediatric Origins of Health Across the Lifespan
体力活动分子传感器儿科临床中心 (MoTrPAC):绘制儿科全生命周期健康起源的运动分子图谱
  • 批准号:
    10391626
  • 财政年份:
    2016
  • 资助金额:
    $ 17.5万
  • 项目类别:
A Pediatric Clinical Center for Molecular Transducers of Physical Activity (MoTrPAC): Towards a Molecular Map of Exercise in the Pediatric Origins of Health Across the Lifespan
体力活动分子传感器儿科临床中心 (MoTrPAC):绘制儿科全生命周期健康起源的运动分子图谱
  • 批准号:
    10265121
  • 财政年份:
    2016
  • 资助金额:
    $ 17.5万
  • 项目类别:
A Pediatric Clinical Center for Molecular Transducers of Physical Activity (MoTrPAC): Towards a Molecular Map of Exercise in the Pediatric Origins of Health Across the Lifespan
体力活动分子传感器儿科临床中心 (MoTrPAC):绘制儿科全生命周期健康起源的运动分子图谱
  • 批准号:
    10320793
  • 财政年份:
    2016
  • 资助金额:
    $ 17.5万
  • 项目类别:
A Pediatric Clinical Center for Molecular Transducers of Physical Activity (MoTrPAC): Towards a Molecular Map of Exercise in the Pediatric Origins of Health Across the Lifespan
体力活动分子传感器儿科临床中心 (MoTrPAC):绘制儿科全生命周期健康起源的运动分子图谱
  • 批准号:
    9246359
  • 财政年份:
    2016
  • 资助金额:
    $ 17.5万
  • 项目类别:

相似海外基金

Establishing best practices for the use of accelerometer measured ambient light sensor data to assess children's outdoor time
建立使用加速度计测量的环境光传感器数据来评估儿童的户外时间的最佳实践
  • 批准号:
    10731315
  • 财政年份:
    2023
  • 资助金额:
    $ 17.5万
  • 项目类别:
Training of machine learning algorithms for the classification of accelerometer-measured bednet use and related behaviors associated with malaria risk
训练机器学习算法,用于对加速计测量的蚊帐使用和与疟疾风险相关的相关行为进行分类
  • 批准号:
    10727374
  • 财政年份:
    2023
  • 资助金额:
    $ 17.5万
  • 项目类别:
Development of environmentally robust and thermally stable Microelectromechanical Systems (MEMS) based accelerometer for automotive applications
开发适用于汽车应用的环境稳定且热稳定的微机电系统 (MEMS) 加速度计
  • 批准号:
    566730-2021
  • 财政年份:
    2022
  • 资助金额:
    $ 17.5万
  • 项目类别:
    Alliance Grants
Use of accelerometer and gyroscope data to improve precision of estimates of physical activity type and energy expenditure in free-living adults
使用加速度计和陀螺仪数据来提高自由生活成年人身体活动类型和能量消耗的估计精度
  • 批准号:
    10444075
  • 财政年份:
    2022
  • 资助金额:
    $ 17.5万
  • 项目类别:
Use of accelerometer and gyroscope data to improve precision of estimates of physical activity type and energy expenditure in free-living adults
使用加速度计和陀螺仪数据来提高自由生活成年人身体活动类型和能量消耗的估计精度
  • 批准号:
    10617774
  • 财政年份:
    2022
  • 资助金额:
    $ 17.5万
  • 项目类别:
Exploration of novel pathophysiology of chemotherapy-induced peripheral neuropathy utilizing quantitative sensory testing and accelerometer
利用定量感觉测试和加速度计探索化疗引起的周围神经病变的新病理生理学
  • 批准号:
    22K17623
  • 财政年份:
    2022
  • 资助金额:
    $ 17.5万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Investigating the validity and reliability of accelerometer-based measures of physical activity and sedentary time in toddlers (iPLAY)
研究基于加速度计的幼儿体力活动和久坐时间测量的有效性和可靠性 (iPLAY)
  • 批准号:
    475451
  • 财政年份:
    2022
  • 资助金额:
    $ 17.5万
  • 项目类别:
    Studentship Programs
Investigating the reliability of accelerometer-based measures of physical activity and sedentary time in toddlers
研究基于加速度计的幼儿体力活动和久坐时间测量的可靠性
  • 批准号:
    466914
  • 财政年份:
    2021
  • 资助金额:
    $ 17.5万
  • 项目类别:
    Studentship Programs
Doctoral Dissertation Research: Leveraging Intensive Time Series of Accelerometer Data to Assess Impulsivity and Inattention in Preschool Children
博士论文研究:利用加速计数据的密集时间序列来评估学龄前儿童的冲动和注意力不集中
  • 批准号:
    2120223
  • 财政年份:
    2021
  • 资助金额:
    $ 17.5万
  • 项目类别:
    Standard Grant
Development of a rotation-invariant accelerometer for human activity recognition
开发用于人类活动识别的旋转不变加速度计
  • 批准号:
    21K19804
  • 财政年份:
    2021
  • 资助金额:
    $ 17.5万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了