Exploring Sustainable Antibacterial Solutions for Personal Hygiene Products

抗菌剂，包括肽和衍生物，分子机制，细菌生长抑制的实时可视化方法，表面与细菌相互作用的分析测量，工业应用的表面固定方法，稳定性和迁移研究。本项目主要研究抗菌纤维和非织造材料在个人卫生产品中的应用机理。抗微生物剂（AMA）可以是肽，例如聚赖氨酸、乳链菌肽和防御素或衍生物，其作用模式从微生物细胞膜破坏到代谢破坏不等。植物来源的抗微生物剂如绿色茶和维生素E也对驱动协同作用非常感兴趣。由于AMA需要牢固地附着在纤维基材上以提供耐用性能并最大限度地降低迁移风险，因此将开发和评估能够更好地固定的表面改性或接枝策略，以实现工业规模扩大的可行性。科学见解有望使公司拥有的新材料/技术开发成为可能。该项目还旨在创造和开发新的能力，用于真实的实时可视化/测量AMA-细菌相互作用。需要考虑真实的应用和老化条件，以支持婴儿/股骨护理业务中的项目。

Antimicrobial agents including peptides and derivatives, molecular mechanisms, real-time visualization methods of bacterial growth inhibition, analytical measurements of surface interactions with bacteria, surface immobilization approach that is practical for industrial application, stability, and migration studies. This project focuses on studying the mechanisms of antibacterial fibre and nonwoven materials for application in personal hygiene products. Antimicrobial agents (AMA) can be peptides such as polylysine, nisin and defensin or derivatives with mode of actions varying from microbial cell membrane disruption to metabolic disruption. Antimicrobials of plant origin like Green Tea and Vitamin E are also of great interest for driving the synergy. As AMA needs to be robustly attached on fibre substrates to deliver durable performance and minimize migration risk, surface modification or grafting strategies enabling better immobilisation will be developed and evaluated for industrial scale-up feasibility. The scientific insights are expected to enable new material/technology developments that are ownable to the company. The project also aims to create and develop novel capabilities for visualizing/measuring the AMA-bacteria interactions in real time. Real application and aging conditions need to be factored in for supporting the projects in Baby/Fem Care business.