Investigating the Enantioselective Introduction of Fluorine into Saturated Molecular Frameworks

氟原子可以对小分子的物理性质有很大的影响，因此开发引入氟的方法是很重要的。在饱和的框架中，氟的引入通常会产生新的立体中心，但这些中心很难控制，因此往往会产生外消旋混合物。在这个项目中，我们正在研究以对映体选择性的方式实现这一目标的新方法，使用菲普斯小组正在开发的新的催化方法。

Fluorine atoms can have a big effect on the physical properties of small molecules and so the development of methods for the introduction of fluorine is important. In saturated frameworks the introduction of fluorine often generates new stereocentres but these are very difficult to control and so racemic mixtures often ensue. In this project we are investigating new methods to achieve this in an enantioselective manner using novel catalytic approaches under development in the Phipps group.