Rochester Epidemiology Project

描述（由申请人提供）：本竞争性续期申请要求继续为罗切斯特流行病学项目（REP）提供核心支持，该项目是明尼苏达州奥姆斯特德县居民医疗保健提供者的病历链接系统。这一独特的数据资源记录了从20世纪初到现在为社区居民提供的医疗保健，并支持了几乎所有研究设计和该国发生的大多数疾病实体的基于人群的流行病学调查。REP支持了马约诊所和其他学术机构的大量研究人员的工作，这些研究机构允许对具有重大社会影响的疾病进行有效的壁外支持研究，包括25项R 01和其他研究赠款，6项计划项目/中心赠款和17项奖学金/培训赠款。自40年前首次资助以来，已有1,500多篇基于REP的手稿发表在同行评审文献中，其中包括自四年前我们上次竞争性更新以来的351篇。 赠款的每一个周期都提供了一个机会，不仅可以维持核心记录的联系功能，而且还可以提高其效用。对于我们的下一个项目周期，我们建议通过继续统计奥姆斯特德县的人口并将其与医疗事件联系起来来更新数据资源（目标1）;整理可用于增强遗传研究的信息，例如存档生物标本的存在，遗传多态性和出生证信息的分发（目标2），以及加强数据安全和改善对最终使用REP（目标3）的用户。这建立在我们从上一个供资期取得的成就的基础上，这些成就包括更及时地收集数据，增加新的信息来源，以及开发工具以增加访问的便利性，同时提供更大的数据安全性。因此，下一个资助周期计划的努力将为越来越多的临床研究人员提供更多的数据可用性，他们与流行病学家，统计学家和基础科学家组成的多学科团队一起，正在利用新科学来解决重大问题，目标是将发现转化为改进的医疗实践和改善NIH路线图中概述的人口健康。

DESCRIPTION (provided by applicant): This competitive renewal application requests continuation of core support for the Rochester Epidemiology Project (REP), the medical record linkage system for health care providers to residents of Olmsted County, Minnesota. This unique data resource chronicles the medical care delivered to community residents from the early 1900's to the present and has supported population-based epidemiologic investigations of virtually every study design and of most disease entities occurring in this country. The REP has supported the work of a large number of investigators at Mayo Clinic and other academic institutions permitted the efficient conduct of extramurally-supported studies of conditions with substantial societal impact, including 25 R01 and other research grants, 6 program project/center grants and 17 fellowship/training grants. Since first funded 40 years ago, more than 1,500 manuscripts based on the REP have been published in the peer-reviewed literature, including 351 since our last competitive renewal four years ago These extensive data from a geographically-defined population are virtually unparalleled in this country, and it is essential that this important research resource be preserved and continually updated. Each cycle of this grant has presented an opportunity to not only maintain the core record linkage function, but to enhance its utility as well. For our next project cycle, we propose to update the data resources through the continued enumeration of the population of Olmsted County and linking them with medical events (Aim 1); collate information that can be used to augment genetic studies such as the existence of archived biologic specimens, distributions of genetic polymorphisms and birth certificate information (Aim 2) and enhancing data security and improving logistical support for end-users of the REP (Aim 3). This builds on our accomplishments from the previous funding period that include better timeliness of data collection, addition of new sources of information, and development of tools to increase ease of access while providing greater data security. Thus, the efforts planned for this next funding cycle will provide increased data availability for the growing pool of clinical investigators who, in conjunction with multidisciplinary teams of epidemiologists, statisticians and basic scientists, are exploiting the new sciences to address significant questions with a goal of translating findings into improved medical practice and better health for the population as outlined in the NIH Road Map.