Training Program in Transplantation

描述(由申请人提供)： 在过去的6年里，路易斯维尔大学战略性地招募了一批富有活力的国际公认的移植研究人员，其中许多人是经验丰富的成熟团队。该小组准备建立一个尖端的博士后研究员，在移植生物学方面获得课程，以培养下一代科学家。这项提案直接针对NIH培训拨款计划的使命，以帮助确保拥有一支多样化和训练有素的劳动力队伍，担任与国家生物医学研究议程相关的领导角色。受训人员将与一名或多名教职员工一起进行基础研究，并开设免疫学、干细胞生物学和移植方面的审计课程。 学员必须拥有生物化学、免疫学、微生物学、生理学、遗传学及相关领域的博士学位，或医学硕士或医学博士学位，并将从该项目教员收到的申请中挑选出来。申请者将被要求提交一份简历，发表名单，3封推荐信，以及一份关于所提议的具体研究的陈述。由方案主任和选定的高级培训人员组成的培训委员会将从这些申请中挑选受训人员。学员将与他们的导师一起准备一份书面培训计划，包括课程作业、实验室培训和研究说明，并将由培训委员会审查和批准。将通过每周与一名或多名培训员举行会议、在每周系列研讨会上介绍研究成果以及书面年度报告来监测受训人员的进展情况，以获得更多年的支助。受训人员将出版手稿，定期出席研究会议并在会上介绍他们的工作，并提交外部资助的赠款申请。培训计划的中心整合重点将是讲座系列，包括每周一次的移植免疫学和干细胞生物学实验室研讨会；每周联合免疫学期刊俱乐部；客座教授系列；移植会议系列；癌症中心化学诱导剂系列；以及研究研讨会系列。这些讲座不仅提供了一个发展演讲技能的舞台，而且还为来自世界各地的移植和相关领域的专家提供了一个作为演讲者参加的场所。 该培训项目的教职员工具备成功实施该项目的研究背景、专业知识和设施。布朗癌症中心细胞治疗研究所拥有设备齐全的中心实验室，以及外科、生理学、生物物理学、内科、分子生物学、心脏病学、儿科、生物化学、药理学和毒理学、眼科、微生物学和免疫学、内科、病理学、神经外科、解剖科学、医学伦理学、生物统计学和神经生物学。大多数培训师也是研究所和中心的成员，这些研究所和中心致力于将具有广泛补充移植兴趣的多学科团体聚集在一起。因此，博士后研究员可以接触到各种各样的技术和广泛的培训经验。我们的目标是，经过3年的培训，学员将有资格承担与移植和干细胞生物学相关的研究职位，在工业、学术界和生物技术领域。

DESCRIPTION (provided by applicant): Over the past 6 years, a dynamic group of internationally recognized investigators in transplantation have been strategically recruited to the University of Louisville, many as seasoned, established teams. This group is poised to establish a cutting-edge Postdoctoral Research Fellow gaining program in transplantation biology to educate the next generation of scientists. This proposal directly addresses the mission of the NIH training grant program to help ensure that a diverse and highly trained workforce is available to assume leadership roles related to the nation's biomedical research agenda Trainees will undertake basic research with one or more faculty members and audit courses in immunology, stem cell biology, and transplantation. Trainees must have either a Ph.D. in biochemistry, immunology, microbiology, physiology, genetics, and related areas, or a D.V.M. or M.D. and will be selected from applications received by faculty in this program. Applicants will be required to submit a CV, publication list, 3 letters of recommendation, and a statement of the specific research proposed. A Training Committee comprised of the program Director and selected senior trainers will select the trainees from among these applications. Trainees will prepare, with their mentor, a written training plan including coursework, laboratory training, and research description which will be reviewed and approved by the Training Committee. The progress of trainees will be monitored by weekly meetings with one or more trainers, presentation of the research results at the weekly seminar series, and written annual reports for additional years of support. Trainees will be expected to publish manuscripts, regularly attend and present their work at research meetings, and submit grant applications for external funding. A central integrating focus of the training program will be the lecture series comprised of weekly laboratory seminars in transplantation immunology and stem cell biology; weekly joint immunology journal club; visiting professor series; transplant conference series; cancer center chemoattractant series; and the research seminar series. These lectures not only provide an arena to develop presentation skills but also provide a venue in which experts in transplantation and related areas from throughout the world participate as speakers. The faculty in this training program has the research background, expertise, and facilities to successfully conduct this program. Well-equipped, centrally-located laboratories exist at the Institute for Cellular Therapeutics, Brown Cancer Center, and Departments of Surgery, Physiology, Biophysics, Medicine, Molecular Biology, Cardiology, Pediatrics, Biochemistry, Pharmacology and Toxicology, Ophthalmology, Microbiology and Immunology, Internal Medicine, Pathology, Neurological Surgery, Anatomical Sciences, Medical Ethics, Biostatistics, and Neurobiology. Most trainers are also members of Institutes and Centers that serve to bring together multidisciplinary groups with interests that broadly complement transplantation. Postdoctoral fellows therefore have access to a wide variety of techniques and breadth of training experience. It is our goal that after 3 years of training, trainees will be qualified to assume research positions related to transplantation and stem cell biology in industry, academia, and biotechnology.