Physicochemical characterisation of oligonucleotides for therapeutic formulations

虽然寡核苷酸是有前景的治疗剂，但它们的制剂具有挑战性，因为它们在较高浓度下具有相当大的和不可预测的粘度，这是通过注射递送的障碍。使用一系列物理化学分析工具来研究分子间和分子内相互作用，该项目旨在对寡核苷酸粘度如何与其物理化学性质相关产生基本理解，并将这些知识应用于控制寡核苷酸制剂粘度，从而能够将这些有前途的化合物作为注射药物递送。

While oligonucleotides are promising therapeutics, their formulation is challenging because of their considerable and unpredictable viscosity at higher concentrations which is an obstacle to delivery by injection. Using a range of physicochemical analysis tools to study inter- and intramolecular interactions, this project aims to generate fundamental understanding of how oligonucleotide viscosity is related to their physicochemical properties and apply this knowledge to control oligonucleotide formulation viscosity, enabling delivery of these promising compounds as injectable medicines.