Immunopathology Training Grant

描述（由申请人提供）：本申请是为了支持加州大学洛杉矶分校细胞和分子病理学研究生项目的博士前研究员的培训，他们的研究兴趣在免疫病理学和炎症领域。细胞和分子病理学项目是加州大学洛杉矶分校病理和检验医学系的博士学位授予单位。该课程的一个显著特点是培养学生在免疫学和病理学领域之间架起桥梁。后一个目标是通过参加特别研讨会和病理大会诊报告，与细胞和分子病理学培训计划教师（其中许多是执业病理学家）的互动以及教学课程计划来实现的。所有学生都要完成细胞生物学和分子遗传学的课程，以及一门核心病理学课程，其中包括基本病理学概念的指导，如炎症和修复，以及旨在理解疾病机制的讲座。此外，免疫病理学学员将被要求完成高级免疫学课程和额外的免疫病理学研究课程。因此，在他们预期的五年培训过程中，受训者将学会将细胞水平的发现与系统过程相结合，并获得将临床领域定义的问题转化和回答到实验室台的专业知识，反之亦然。超过一半的研究生课程教师，以及目前在细胞和分子病理学项目注册的34名博士前研究员中的17名，在免疫病理学/炎症领域进行研究。在转入细胞和分子病理学专业之前，该项目的大多数学生都是通过UCLA ACCESS进入加州大学洛杉矶分校的，这是一个由11个部门联合管理的招生过程和第一年的课程。其他学员包括医学博士/博士候选人，以及正在攻读博士学位的执业医学博士。具体的研究课题包括淋巴细胞发育、趋化因子和抗微生物肽在宿主防御和炎症中的作用、免疫系统细胞在促进炎症过程中的作用、移植生物学、微生物发病机制和调节单核细胞活化的核受体。这项研究是在病理和检验医学系进行的。

DESCRIPTION (provided by applicant): This application is being submitted to support the training of pre-doctoral fellows, enrolled in the Cellular and Molecular Pathology Graduate Program at UCLA, with research interests in the area of Immunopathology and Inflammation. The Cellular and Molecular Pathology Program is the Ph D granting unit of the Department of Pathology and Laboratory Medicine at UCLA. A distinguishing feature of this program is that students are trained to bridge the gap between the fields of immunology and pathology. This latter goal is accomplished through attendance at special seminars and Pathology Grand Rounds presentations, interactions with Cellular and Molecular Pathology training program faculty, many of whom are practicing pathologists, and a program of didactic coursework. All students complete courses in cell biology and molecular genetics and a core Pathology course in which instruction in basic pathologic concepts, such as inflammation and repair, and lectures designed to understand mechanisms of disease are presented. In addition, immunopathology trainees will be required to complete an advanced immunology course and additional research courses in immunopathology. As a result, over the course of their anticipated five years of training, trainees will learn to integrate findings at the cellular level with systemic processes and obtain the expertise to translate and answer questions defined in the clinical area to the laboratory bench and vice-versa. Over half of the graduate program faculty, as well as 17 of the 34 pre-doctoral fellows currently enrolled in the Cellular and Molecular Pathology program, conduct research in the area of immunopathology/inflammation. Most students in the program entered UCLA via UCLA ACCESS, an admissions process and first year curriculum jointly administered by 11 departments, prior to transfer into the Cellular and Molecular Pathology program. Additional trainees are M D/Ph D candidates as well as practicing M D's who are undertaking Ph D studies. Specific research topics being studied include lymphocyte development, actions of chemokines and anti-microbial peptides in host defense and inflammation, the role of immune system cells in promoting inflammatory processes, transplantation biology, microbial pathogenesis, and nuclear receptors that regulate monocyte activation. This research is conducted in the Department of Pathology and Laboratory Medicine.