Immunopathology Training Grant

描述（由申请人提供）：本申请正在提交，以支持在加州大学洛杉矶分校的细胞和分子病理学研究生课程就读的博士前研究员的培训，在免疫病理学和炎症领域的研究兴趣。细胞和分子病理学项目是加州大学洛杉矶分校病理学和实验室医学系的博士授予单位。该计划的一个显着特点是，学生接受培训，以弥合免疫学和病理学领域之间的差距。后一个目标是通过参加特别研讨会和病理学大圆桌会议的演示，与细胞和分子病理学培训计划教师的互动，其中许多人是执业病理学家，以及教学课程计划来实现的。所有学生完成细胞生物学和分子遗传学课程以及核心病理学课程，其中介绍了基本病理学概念，如炎症和修复，以及旨在了解疾病机制的讲座。此外，免疫病理学学员将被要求完成一个先进的免疫学课程和免疫病理学的额外研究课程。因此，在他们预期的五年培训期间，学员将学习将细胞水平的发现与系统过程相结合，并获得专业知识，将临床领域定义的问题翻译和回答到实验室工作台，反之亦然。超过一半的研究生课程教师，以及目前在细胞和分子病理学计划就读的34名博士前研究员中的17名，在免疫病理学/炎症领域进行研究。该计划的大多数学生通过UCLA ACCESS进入UCLA，这是一个由11个部门联合管理的招生程序和第一年课程，然后转入细胞和分子病理学计划。额外的学员是医学博士/博士候选人以及正在进行博士研究的执业医学博士。正在研究的具体研究课题包括淋巴细胞发育，趋化因子和抗微生物肽在宿主防御和炎症中的作用，免疫系统细胞在促进炎症过程中的作用，移植生物学，微生物发病机制和调节单核细胞活化的核受体。本研究在病理学和实验室医学系进行。

DESCRIPTION (provided by applicant): This application is being submitted to support the training of pre-doctoral fellows, enrolled in the Cellular and Molecular Pathology Graduate Program at UCLA, with research interests in the area of Immunopathology and Inflammation. The Cellular and Molecular Pathology Program is the Ph D granting unit of the Department of Pathology and Laboratory Medicine at UCLA. A distinguishing feature of this program is that students are trained to bridge the gap between the fields of immunology and pathology. This latter goal is accomplished through attendance at special seminars and Pathology Grand Rounds presentations, interactions with Cellular and Molecular Pathology training program faculty, many of whom are practicing pathologists, and a program of didactic coursework. All students complete courses in cell biology and molecular genetics and a core Pathology course in which instruction in basic pathologic concepts, such as inflammation and repair, and lectures designed to understand mechanisms of disease are presented. In addition, immunopathology trainees will be required to complete an advanced immunology course and additional research courses in immunopathology. As a result, over the course of their anticipated five years of training, trainees will learn to integrate findings at the cellular level with systemic processes and obtain the expertise to translate and answer questions defined in the clinical area to the laboratory bench and vice-versa. Over half of the graduate program faculty, as well as 17 of the 34 pre-doctoral fellows currently enrolled in the Cellular and Molecular Pathology program, conduct research in the area of immunopathology/inflammation. Most students in the program entered UCLA via UCLA ACCESS, an admissions process and first year curriculum jointly administered by 11 departments, prior to transfer into the Cellular and Molecular Pathology program. Additional trainees are M D/Ph D candidates as well as practicing M D's who are undertaking Ph D studies. Specific research topics being studied include lymphocyte development, actions of chemokines and anti-microbial peptides in host defense and inflammation, the role of immune system cells in promoting inflammatory processes, transplantation biology, microbial pathogenesis, and nuclear receptors that regulate monocyte activation. This research is conducted in the Department of Pathology and Laboratory Medicine.