Autoimmunity and Immunopathology Training Program

描述（由申请人提供）：这是匹兹堡大学医学院的一个新的自身免疫和免疫病理学培训项目。我们相信，自身免疫和免疫病理学的研究为年轻科学家提供了具有挑战性和令人兴奋的机会。充分的培训需要深入了解免疫学和免疫病理学临床方面的当代概念。在自身免疫和免疫病理学这个拟议的培训计划的目标是产生优秀的学员（四个博士前和三个博士后）进行跨学科，前沿研究的能力。我们将在匹兹堡大学现有的转化研究优势的基础上。此外，匹兹堡大学在自身免疫研究领域拥有专业知识的新成员意味着现在有大量的研究人员来提供这一急需的培训计划。我们的一些教师从事临床前研究，然后在临床上进行测试。我们将通过汇集教师和学员进行相关的自身免疫和免疫病理学（免疫学，细胞生物学，分子遗传学和临床流变学）的研究来实现这一目标。该方案是在一个大的框架内提出的。跨学科生物医学研究生课程（IBGP）位于匹兹堡大学医学院，鼓励多个学科之间的互动，使学员能够掌握当代生物学的不同领域。拟议的计划还借鉴了已建立的免疫学（IMM）研究生课程和匹兹堡大学几个临床部门（包括关节炎研究所）的其他教师。IMM研究生课程由医学院几个部门的教师组成，并与关节炎研究所提供的专业培训一起，提供全面的正式入门和专业课程，将提供自身免疫和免疫病理学的统一培训。这项拟议的培训计划是由教师启用和支持，教师在自身免疫，免疫病理学和相关领域的研究，最近扩大的设施，并在匹兹堡大学强有力的机构支持的培训师的良好记录。 相关性（参见说明）：自身免疫性疾病和免疫病理学疾病的发病率不断增加，加上许多这些疾病缺乏有效的治疗方法，这突出表明需要招募年轻科学家来选择研究这些疾病的职业。该计划还将解决进入流变学和相关学科领域的医生科学家的国家短缺问题。

DESCRIPTION (provided by applicant): This is a new training program in Autoimmunity and Immunopathology at the University of Pittsburgh School of Medicine. We believe that research in autoimmunity and immunopathology provides challenging and exciting opportunities for young scientists. Adequate training requires intense exposure to contemporary concepts in immunology and clinical aspects of immunopathology. The goal of this proposed training program in autoimmunity and immunopathology is to produce outstanding trainees (four predoctoral and three postdoctoral) with the ability to perform interdisciplinary, cutting-edge research. We will build on the existing strengths in translational research here at the University of Pittsburgh. In addition, new recruits to the University of Pittsburgh with expertise in the area of autoimmunity research mean that there is now a critical mass of investigators to provide this much needed training program. Several of our faculty are engaged in preclinical studies which are then tested in the clinic. We will achieve this by bringing together faculty and trainees performing research related to autoimmunity and immunopathology (immunology, cell biology, molecular genetics and clinical rheumatology). The proposed program is within the framework of a large. Interdisciplinary Biomedical Graduate Program (IBGP) based in the University of Pittsburgh, School of Medicine that encourages interactions among several disciplines and that enables trainees to master different fields of contemporary biology. The proposed program also draws from the established Immunology (IMM) Graduate Program and additional faculty in several University of Pittsburgh clinical departments, including the Arthritis Institute. The IMM graduate programs consist of faculty from several departments in the School of Medicine, and together with the specialized training provided by the Arthritis Institute, offer a comprehensive range of formal introductory and specialized courses that will afford unified training in autoimmunity and immunopathology. This proposed training program is enabled and supported by faculty with strong records as trainers in autoimmunity, immunopathology and related areas of research, recently- expanded facilities, and strong Institutional support at the University of Pittsburgh. RELEVANCE (See instructions): The increasing incidence of autoimmune and immunopathological conditions coupled with a lack of effective therapies for many of these diseases highlights the need to recruit young scientists to choose a career in investigating these diseases. This program will also address the national shortage of physician-scientists entering the field of rheumatology and related disciplines.