Urologic Oncology Research Training Grant

描述（由申请人提供）：MSKCC泌尿肿瘤研究培训计划（RTP）旨在培养泌尿肿瘤学术领袖。自近50年前设立奖学金项目以来，已培训了180多名研究员。每年从25-40名申请者中面试8-15名高素质的候选人，接受3-9名博士后研究员，所有符合委员会资格的泌尿科医生都完成了住院医师。这些学生中每年有两名获得T32培训基金的资助，在MSKCC、康奈尔大学威尔医学院或洛克菲勒大学的资深科学家导师的指导下进行为期两年的研究，研究领域包括免疫学、生物成像、分子遗传学或生物统计学。具体的研究项目包括基因修饰T淋巴细胞的过继免疫治疗，针对PSMA的单克隆抗体作为成像和治疗剂，以及前列腺癌的基因表达分析。迄今为止任命的11名研究员中，4人正在培训，7人已经毕业，6人现在是主要大学的助理教授。研究员需要参加结构化的多学科临床和研究会议，并在MSKCC研讨会和国家会议上展示他们的工作。他们接受临床研究方法、生物统计学、研究伦理和人类受试者监管问题的正式指导。自最初的奖项以来，我们的项目有了长足的发展。泌尿外科的师资队伍增加了一倍，研究导师的质量和多样性都有所提高，奖学金申请者的数量和质量也在稳步增长。泌尿肿瘤学的RTP对我们的奖学金至关重要，它支持致力于研究培训的泌尿科医生为独立研究者的职业生涯做准备。我们超过50年的经验证实，他们将成为下一代泌尿肿瘤学的领导者，他们的工作将有助于降低GU癌症的发病率。

DESCRIPTION (provided by applicant): The Research Training Program (RTP) in Urologic Oncology at MSKCC is designed to train academic leaders in urologic oncology. Over 180 fellows have been trained since the fellowship program was established nearly 50 years ago. Each year 8-15 highly qualified candidates are interviewed from a pool of 25-40 applicants, 3-9 are accepted as post-doctoral fellows, all board-eligible urologists who have completed residency. Two of these are selected each year as research career awardees supported by our T32 training grant, initially funded in 1999, to spend 2 years in research with a senior scientist mentor at MSKCC, Weill Medical College of Cornell University or Rockefeller University, in an appropriate field such as immunology, biological imaging, molecular genetics, or biostatistics. Specific research projects have included adoptive immunotherapy with genetically modify T lymphocytes, monoclonal antibodies against PSMA as imaging and therapeutic agents, and gene expression analysis of prostate cancers. Of 11 fellows appointed to date, 4 are in training, 7 have graduated, and 6 are now assistant professors at major universities. Fellows are required to participate in structured, multidisciplinary clinical and research conferences and to present their work at MSKCC seminars and national meetings. They receive formal instruction in clinical research methodology, biostatistics, research ethics, and human subjects regulatory issues. Our program has grown substantially since the original award. The faculty in urology has doubled, the quality and diversity of research mentors has increased and the number and quality of fellowship applicants have grown steadily. The RTP in urologic oncology is essential to our fellowship, supporting urologists committed to research training to prepare for a career as independent investigators. Our experience over 50 years confirms that they will become leaders of urologic oncology in the next generation whose work will help decrease morbidity from GU cancers.