Genomic characterisation of novel inflammatory regulators in a mouse model of disseminated Candidiasis
Genomic characterisation of novel inflammatory regulators in a mouse model of disseminated Candidiasis
批准号:
nhmrc : 597452
负责人:
A/Pr Robert Ashman
金额:
$38.77万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
基因组生物学为免疫功能的研究提供了巨大的希望,但需要新的方法来建立数据和疾病之间的见解。该项目着眼于易受酵母菌感染的小鼠所使用的基因产物,并询问这些信息是否在抗性动物中有不同的使用。医院中的血源性真菌感染正在增加;我们希望发现新的免疫基因产物,并了解它们是如何起作用的,这样我们就可以更好地预测感染的结果。
英文摘要
Genome biology offers great promise for the study of immune function, but new approaches are needed to build insights between data and disease. This project looks at the gene products used by mice susceptible to yeast infection and asks if the information is used differently in resistant animals. Blood-borne fungal infections are increasing in hospitals; we want to discover new immune gene products and understand how they contribute, so we can better predict the outcome of an infection.
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会议论文
The c-type lectin, Mincle, is a macrophage receptor for Candida albicans.
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批准号:nhmrc : 455947
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项目类别:NHMRC Project Grants
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资助金额:$31.02万
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财政年份:2007
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负责人:A/Pr Robert Ashman
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依托单位:
Host resistance and protection against oral candidasis
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批准号:nhmrc : 143067
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项目类别:NHMRC Project Grants
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资助金额:$13.1万
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财政年份:2001
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负责人:A/Pr Robert Ashman
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依托单位:
Genetic and immunological determinants of susceptibility to mucosal infection with candida albicans
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批准号:nhmrc : 980399
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项目类别:NHMRC Project Grants
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资助金额:$21.09万
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财政年份:1998
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负责人:A/Pr Robert Ashman
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依托单位:
海外基金