Regenerative Medicine Training Grant

描述(由申请人提供)： 本申请寻求为期五年的干细胞生物学和再生医学培训计划的资金，以支持六名博士后实习生和两名博士后研究员，目的是培养能够维持干细胞生物学和在患者护理中使用干细胞/干细胞产品的生产性研究计划的独立研究人员。该计划由来自佛罗里达大学盖恩斯维尔分校医学和工程学院10个系(分子遗传学和微生物学/神经科学/儿科/病理学、免疫学和实验室医学/生理学和功能基因组学/医学/材料科学和工程/麦克奈特脑研究所/整形外科和康复/UF斯汉兹癌症中心)的15名初级教员组成。该项目的教职员工是基础和临床科学家的混合体，由久负盛名、资金充裕的研究人员组成，他们在干细胞生物学领域，特别是在成体干细胞领域，横跨神经、造血、内分泌、肝胆和皮肤干细胞生物学，获得了国内外的广泛赞誉。这些调查人员也有很强的学生指导历史。除了被列为关键人员的主要P受体外，还提供了一些年轻研究人员(哈夫、科恩、科格尔和其他人)的信息，他们拥有非常活跃和有前途的学术生涯，他们的参与将扩大和丰富该计划涵盖的研究领域。这些调查人员在收到R01或同等的外部资金后，将被视为正式计划成员。 将与医学院的生物医学科学跨学科项目(IDP)合作，招募博士前实习生并进行初步培训。每年平均有40-50名潜在候选人，他们从全美各地招收佛罗里达大学。这些博士生的平均口语和定量GRE成绩为1250分，GPA为3.5分。IDP提供全面的课堂培训、实验室入门课程、实验室轮换和专门学科的高级课程工作。随后的培训侧重于独立的实验室研究，辅以强调交流技能的具体项目活动。博士前培训需要大约5年时间。虽然第一年的博士前支持将来自医学院，但预计平均3年的支持将来自培训补助金，其余的支持来自导师的研究补助金或其他外部来源。 博士后实习生将在全国范围内招收博士和医学博士。对博士后研究员的培训将几乎完全集中在实验室研究上，辅以研讨会、期刊俱乐部和选定的课程工作，例如伦理学。博士后培训需要大约2-3年，培训补助金最多支持两年。

DESCRIPTION (provided by applicant): This application seeks five years of funding for a training program in Stem Cell Biology & Regenerative Medicine to support six pre-doctoral trainees and two post-doctoral fellows with the aim of producing independent investigators capable of sustaining productive research programs in stem cell biology and use of stem cells / stem cell products in patient care. The program comprises 15 primary faculty preceptors from 10 departments (Molecular Genetics & Microbiology / Neuroscience / Pediatrics / Pathology, Immunology & Laboratory Medicine / Physiology and Functional Genomics / Medicine / Materials Science and Engineering / McKnight Brain Institute / Orthopaedics and Rehabilitation / UF Shands Cancer Center) within the Colleges of Medicine and Engineering at the University of Florida, Gainesville. The program faculty is a mix of basic and clinical scientists and is comprised of well-established and well-funded investigators that have received much national and international acclaim in stem cell biology, especially in the area of adult stem cells, spanning neural, hematopoeitic, endocrine, hepatobiliary and dermal stem cell biology. These investigators also have a strong history of student instruction. In addition to the primary Preceptors listed as Key Personnel, information is provided on a number of young investigators (Harfe, Cohn, Cogle and others) with very active and promising academic careers, whose participation will both extend and enrich the research areas covered by the Program. These investigators will be considered full Program members upon receipt of R01 or equivalent extramural funding. Pre-doctoral trainees will be recruited and initially trained in collaboration with the College of Medicine's Interdisciplinary Program in Biomedical Sciences (IDP). The pool of potential candidates averages 40-50 per year, and enroll at the University of Florida from throughout the USA. These pre-doctoral students average combined verbal and quantitative GRE scores of 1250 and GPAs of 3.5. The IDP provides comprehensive classroom training, introductory laboratory courses, laboratory rotations and advanced course work in specialized disciplines. Subsequent training focuses on independent laboratory research supplemented with program-specific activities stressing communicative skills. Pre-doctoral training requires approximately 5 years. While the first year of pre-doctoral support will come from the College of Medicine, it is anticipated that an average of 3 years of support will come from the training grant and the remainder of support from the mentor's research grant or other external sources. Post-doctoral trainees will be recruited nationally at both the Ph.D. and M.D. level. Training for post-doctoral fellows will focus almost exclusively on laboratory research, supplemented with seminars, journal clubs and selected course work, e.g., ethics. Post-doctoral training requires approximately 2-3 years, with a maximum of two years of support from the training grant.