Graduate Training in Stem Cell Biology and Regenerative Medicine

干细胞生物学和再生医学研究生培训

• 批准号: 10208896
• 负责人: IRVING L. WEISSMAN
• 金额: $ 48.46万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10208896
• 关键词: Regenerative Medicine; Training; stem cell biology

PROJECT SUMMARY This new T32 application seeks support for predoctoral training in the newly established doctoral degree program in Stem Cell Biology and Regenerative Medicine (SCBRM) at Stanford University. The SCBRM graduate program is the first new doctoral degree program at the School of Medicine in more than 20 years. The program faculty span multiple schools and departments at Stanford and our primary goal is to train the best scientists in this new discipline through a combination of basic stem cell biology and the role of stem cells in the development, maintenance, and disease pathogenesis of human tissues and organs. Over the last decade, fundamental discoveries in the biomedical and physical sciences have generated a strong climate of expectation that discoveries should and will lead to new medical applications and novel therapies. There is no greater expectation than that produced within the broad discipline of stem cell biology and regenerative medicine, an established area of study that rests squarely on an unprecedented intersection of disciplines. On the one hand, rapid advances in basic biology, genetics, material sciences, nanotechnology, engineering, and physics are providing extraordinary new tools for harnessing stem cells in regenerative medicine. On the other hand, rapid and continued growth of financial investment in translational medicine by national, state, and private entities targets research dollars with an increasing focus on applied science. Research in stem cell biology and regenerative medicine also raises ethical and legal concerns that are unique in all of biological research; thus, this broad intersection of disciplines is producing a new breed of scientist, one with skills that embrace biological and physical sciences, medicine, business, ethics and law. In the following application we outline a novel predoctoral curriculum and training plan that provides a strong foundation in developmental and cellular biology, genetics, and biochemistry. These intellectual strengths are partnered with clinical science, bioengineering, business, ethics and law to produce a new generation of scientist who is both motivated and capable of translating stem cell discoveries into new applications in regenerative medicine.

项目概要 这项新的T32申请寻求新设立的博士学位的博士前培训支持 斯坦福大学干细胞生物学和再生医学（SCBRM）项目。 SCRBRM 研究生项目是医学院20多年来第一个新增的博士学位项目。 该项目的教员遍布斯坦福大学的多个学院和部门，我们的主要目标是培训 通过结合基本干细胞生物学和干细胞的作用，这一新学科的最佳科学家 参与人体组织器官的发育、维持和疾病发病机制。 在过去的十年中，生物医学和物理科学的基本发现产生了 人们普遍期望这些发现应该并且将会带来新的医学应用和新颖的发现 疗法。没有比干细胞生物学这一广泛学科所产生的期望更大的了 和再生医学，一个既定的研究领域，完全建立在前所未有的交叉点上 的学科。一方面，基础生物学、遗传学、材料科学、纳米技术、 工程学和物理学正在为利用干细胞进行再生提供非凡的新工具 药品。另一方面，转化医学的金融投资持续快速增长。 国家、州和私人实体将研究资金投入到应用科学上。 干细胞生物学和再生医学的研究也引起了独特的伦理和法律问题 在所有生物学研究中；因此，这种广泛的学科交叉正在产生新一代的科学家， 一位拥有生物和物理科学、医学、商业、道德和法律技能的人。 在下面的申请中，我们概述了一个新颖的博士前课程和培训计划，提供了强大的 发育和细胞生物学、遗传学和生物化学的基础。这些智力优势是 与临床科学、生物工程、商业、伦理学和法律合作，生产新一代 既有动力又有能力将干细胞发现转化为新应用的科学家 再生医学。

项目成果

Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting.

• DOI: 10.1016/j.omtn.2018.04.017
• 发表时间: 2018-09-07
• 期刊: Molecular therapy. Nucleic acids
• 作者: Charlesworth CT;Camarena J;Cromer MK;Vaidyanathan S;Bak RO;Carte JM;Potter J;Dever DP;Porteus MH
• 通讯作者: Porteus MH

Single amino acid mutations in the Saccharomyces cerevisiae rhomboid peptidase, Pcp1p, alter mitochondrial morphology.

酿酒酵母菱形肽酶 Pcp1p 中的单氨基酸突变会改变线粒体形态。

• DOI: 10.1002/cbin.11219
• 发表时间: 2020
• 期刊: Cell biology international
• 影响因子: 3.9
• 作者: Huddleston,MaryElizabeth;Xiao,Ningyu;Both,AndriesPieter;Gordon,DonnaM
• 通讯作者: Gordon,DonnaM

CXCR2 inhibition in G-MDSCs enhances CD47 blockade for melanoma tumor cell clearance.

• DOI: 10.1073/pnas.2318534121
• 发表时间: 2024-01
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: A. Banuelos;Allison Zhang;Hala Berouti;Michelle Baez;Leyla Yılmaz;Nardin Georgeos;Kristopher D Marjon-Kristop