Graduate Training in Stem Cell Biology and Regenerative Medicine

干细胞生物学和再生医学研究生培训

• 批准号: 10208896
• 负责人: IRVING L. WEISSMAN
• 金额: $ 48.46万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10208896
• 关键词: Regenerative Medicine; Training; stem cell biology

PROJECT SUMMARY This new T32 application seeks support for predoctoral training in the newly established doctoral degree program in Stem Cell Biology and Regenerative Medicine (SCBRM) at Stanford University. The SCBRM graduate program is the first new doctoral degree program at the School of Medicine in more than 20 years. The program faculty span multiple schools and departments at Stanford and our primary goal is to train the best scientists in this new discipline through a combination of basic stem cell biology and the role of stem cells in the development, maintenance, and disease pathogenesis of human tissues and organs. Over the last decade, fundamental discoveries in the biomedical and physical sciences have generated a strong climate of expectation that discoveries should and will lead to new medical applications and novel therapies. There is no greater expectation than that produced within the broad discipline of stem cell biology and regenerative medicine, an established area of study that rests squarely on an unprecedented intersection of disciplines. On the one hand, rapid advances in basic biology, genetics, material sciences, nanotechnology, engineering, and physics are providing extraordinary new tools for harnessing stem cells in regenerative medicine. On the other hand, rapid and continued growth of financial investment in translational medicine by national, state, and private entities targets research dollars with an increasing focus on applied science. Research in stem cell biology and regenerative medicine also raises ethical and legal concerns that are unique in all of biological research; thus, this broad intersection of disciplines is producing a new breed of scientist, one with skills that embrace biological and physical sciences, medicine, business, ethics and law. In the following application we outline a novel predoctoral curriculum and training plan that provides a strong foundation in developmental and cellular biology, genetics, and biochemistry. These intellectual strengths are partnered with clinical science, bioengineering, business, ethics and law to produce a new generation of scientist who is both motivated and capable of translating stem cell discoveries into new applications in regenerative medicine.

项目总结 这一新的T32申请寻求对新设立的博士学位的博士前培训的支持 斯坦福大学干细胞生物学和再生医学(SCBRM)项目。SCBRM 研究生课程是医学院20多年来第一个新的博士学位课程。 该计划的教职员工横跨斯坦福大学的多个学院和系，我们的主要目标是培养 通过将基础干细胞生物学和干细胞的作用相结合，成为这一新学科中最优秀的科学家 在人体组织和器官的发育、维持和疾病发病机制中。 在过去的十年里，生物医学和物理科学的基础发现产生了 强烈的期待气氛，认为发现应该并将导致新的医学应用和创新 治疗。没有比在干细胞生物学的广泛学科中产生的期望更大的期望了。 和再生医学，这是一个建立在一个前所未有的交叉点上的既定研究领域 纪律的问题。一方面，基础生物学、遗传学、材料科学、纳米技术、 工程学和物理学正在为利用再生干细胞提供非凡的新工具 医药。另一方面，转化医学财政投资的快速和持续增长 国家、州和私人实体的目标是研究资金，越来越多地关注应用科学。 干细胞生物学和再生医学的研究也引发了独特的伦理和法律问题。 在所有的生物学研究中；因此，这种广泛的交叉学科正在产生一种新的科学家， 拥有涵盖生物和物理科学、医学、商业、伦理和法律的技能的人。 在下面的申请中，我们概述了一个新的博士前课程和培训计划，该计划提供了一个强有力的 发育和细胞生物学、遗传学和生物化学的基础。这些智力优势是 与临床科学、生物工程、商业、伦理和法律合作，产生新一代 既有动力又有能力将干细胞发现转化为新应用的科学家 再生医学。

项目成果

Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting.

• DOI: 10.1016/j.omtn.2018.04.017
• 发表时间: 2018-09-07
• 期刊: Molecular therapy. Nucleic acids
• 作者: Charlesworth CT;Camarena J;Cromer MK;Vaidyanathan S;Bak RO;Carte JM;Potter J;Dever DP;Porteus MH
• 通讯作者: Porteus MH

Single amino acid mutations in the Saccharomyces cerevisiae rhomboid peptidase, Pcp1p, alter mitochondrial morphology.

酿酒酵母菱形肽酶 Pcp1p 中的单氨基酸突变会改变线粒体形态。

• DOI: 10.1002/cbin.11219
• 发表时间: 2020
• 期刊: Cell biology international
• 影响因子: 3.9
• 作者: Huddleston,MaryElizabeth;Xiao,Ningyu;Both,AndriesPieter;Gordon,DonnaM
• 通讯作者: Gordon,DonnaM

CXCR2 inhibition in G-MDSCs enhances CD47 blockade for melanoma tumor cell clearance.

• DOI: 10.1073/pnas.2318534121
• 发表时间: 2024-01
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: A. Banuelos;Allison Zhang;Hala Berouti;Michelle Baez;Leyla Yılmaz;Nardin Georgeos;Kristopher D Marjon-Kristop