Genotypes and phenotypes of human primary non-congenital antibody deficiency

抗体是免疫系统的关键组成部分，在抵御细菌和病毒感染方面尤为重要。在一些人中，抗体产生失败，使他们更容易受到感染。在大多数情况下，抗体失效的机制尚不清楚。该项目试图确定抗体失效的遗传和细胞机制。这可以提高对免疫缺陷的诊断，并提高我们对免疫系统的整体了解。

Antibodies represent a key component of the immune system, and a particularly important in defence against bacterial and viral infections. In some individuals, antibody production fails, rendering them more susceptible to infection. In most cases, the mechanism of antibody failure is unknown. This project seeks to determine the genetic and cellular mechanisms of antibody failure. This could improve diagnosis for immune deficiency, and improve our overall understanding of the immune system.