Canada Clinical Trials Group Contribution to NCI Program

此应用程序的最终目标是增强我们可靠而高效地回答 癌症的治疗。因为随机临床试验为癌症的有效性提供了最佳证据 治疗，国家癌症研究所通过临床试验合作小组计划资助临床试验 癌症治疗评估计划调查分会。在过去的几年里，发生了实质性的变化 为了促进更快的发展和研究的完成，对临床试验方案进行了改进 这解决了癌症治疗中的重要问题。这些变化对…的行为产生了重大影响 合作的临床试验遍及北美，包括加拿大。 加拿大国家癌症研究所是一个由加拿大癌症协会捐款资助的机构，它支持一项 国家临床试验组(NCIC CTG)，其功能类似于美国组。自1988年以来，NCIC CTG一直是 由美国国立卫生研究院资助，以支持该小组对涉及两个或更多人之间的合作努力的试验的贡献 分组--“组间”试验。本申请目的是以下列方式更新和扩大资金 允许NCIC CTG积极参与临床试验的“新国家体系”。 这项建议的具体目的与我们最初申请时相同；即：1.贡献患者 为NCI赞助的组间试验提供登记、数据管理资源和高质量的数据；2.提供 为NCI组间试验的开发、设计和实施提供科学投入；以及3.提供领导和 为一些NCI组间试验提供协调资源。然而，由于该奖项在 和过去五年临床试验制度的变化，这一应用的重点是我们的领先者角色 大型北美研究。

The ultimate goal of this application is to enhance our ability to answer, reliably and efficiently, critical questions in the treatment of cancer. Because randomized clinical trials provide the best evidence of the effectiveness of cancer treatments, the National Cancer Institute funds a Clinical Trials Cooperative Group Program through the Clinical Investigations Branch of the Cancer Therapy Evaluation Program. In the past few years, substantial changes have been made to the Clinical Trials Program in order to promote the more rapid development and completion of studies that address important issues in cancer treatment. These changes have had a major impact on the conduct of cooperative clinical trials throughout North America, including Canada. The National Cancer Institute of Canada, an agency funded by donations to the Canadian Cancer Society, supports a national clinical trials group (NCIC CTG) that functions similarly to US groups. Since 1988, the NCIC CTG has been funded by NIH to support the Group's contribution to trials that involve a collaborative effort between two or more groups - "intergroup" trials. The purpose of this application is to renew and expand that funding in a manner that will allow the NCIC CTG to participate actively in the "New National System" of clinical trials. The specific aims of the proposal are the same as they were in our initial application; namely: 1. To contribute patient enrolment, data management resources, and high quality data to intergroup trials sponsored by NCI; 2. To provide scientific input into the development, design and conduct of NCI intergroup trials; and 3. To provide leadership and coordination resources for some NCI intergroup trials. However, because of the work supported by this award in the past five years and the changes in the clinical trials system, the emphasis of this application is on our role a leader of large North American studies.