Glucocorticoid resistance: identifying new anti-inflammatory drug targets

控制慢性炎症性疾病，如哮喘，涉及使用与类固醇激素皮质醇有关的药物。高达40%的病情更严重的患者对这些药物反应不佳或根本没有反应。其余的非类固醇治疗仅部分有效。疾病控制不力是一个巨大的健康和经济负担。我们已经确定了类固醇耐药的分子机制，并提出了新的研究，以确定新的药物，以扭转类固醇耐药。

The control of chronic inflammatory diseases such as asthma involve use of drugs related to the steroid hormone cortisol. Up to 40% of patients with more severe disease respond poorly or not at all to these drugs. The remaining non-steroid treatments are only partially effective. Poor disease control is a great health and economic burden. We have identified a molecular mechanism for steroid resistance and propose new studies to identify novel drugs that act to reverse steroid resistance.