Glutathione transferase-derived compounds as therapeutic agents

抑制心脏钙离子通道可能是改善心力衰竭患者心脏功能的有效新途径。该项目将研究谷胱甘肽转移酶如何抑制心脏中的钙离子通道，以及是否可以使用肌肉特异性谷胱甘肽转移酶的小片段特异性地修饰心脏的ryanodine受体功能。这些片段将为开发新的治疗方法提供基础。

Inhibition of cardiac calcium ion channels may be an effective new way of improving heart performance in patients with heart failure. This project will investigate how a glutathione transferase enzyme inhibits calcium ion channels in the heart and if small fragments of a muscle specific glutathione transferase can be used to specifically modify cardiac ryanodine receptor function. These fragments will provide the basis for the development of a new therapeutic approach.