Functional Relevance of Spontaneous BOLD Fluctuations

描述（由申请人提供）： 这项研究的目的是了解即使在没有任务或刺激的情况下，人类大脑的内在持续功能。具体来说，目前的研究将表征功能相关的内在或自发波动的fMRI BOLD信号。这些自发波动对任务相关的BOLD反应的影响以及自发波动对行为的影响将被检查。确定神经活动的自发波动、神经元对刺激的反应以及由此产生的行为之间的关系对于理解大脑的运作至关重要。此外，自发BOLD波动的功能相关性是重要的了解这些波动在不同的病理条件下的干扰。

DESCRIPTION (provided by applicant): The objective of this research is to understand the intrinsic ongoing functionality of the human brain present even in the absence of tasks or stimuli. Specifically, the current study will characterize the functional relevance of intrinsic or spontaneous fluctuations in the fMRI BOLD signal. The effect of these spontaneous fluctuations on task-related BOLD responses as well as the influence of spontaneous fluctuations on behavior will be examined. Determining the relationship between spontaneous fluctuations in neural activity, the neuronal response to a stimulus, and the resulting behavior is critical to understanding the operation of the brain. Further, the functional relevance of spontaneous BOLD fluctuations is important for understanding reported disturbances in these fluctuations in different pathological conditions.