2007 Carbohydrates Gordon Research Conference

描述（由申请人提供）：碳水化合物，特别是在细胞表面发现的碳水化合物，起着关键的生物学作用。例如，糖缀合物参与细胞的发育和分化、细胞粘附和细胞信号传导以及细胞-基质相互作用。还充分证明了这些聚糖结构或碳水化合物结合蛋白表达的变化与越来越多的疾病相关，包括人类遗传性疾病，如肌营养不良或先天性糖基化疾病、病毒和细菌感染、寄生虫入侵和存活以及转移和肿瘤进展。最近发表的研究表明，糖缀合物也是免疫系统的调节剂。戈登碳水化合物研究会议（GRC）的主要目标是汇集在“糖科学”广泛领域工作的不同科学家群体，这个术语广义地说是指碳水化合物化学，碳水化合物生物化学和糖生物学领域，讨论该领域的最新进展和未来挑战。与往年一样，这次会议将涉及具有广泛经验的个人，从资深研究人员到该领域的新人，包括初级教师，博士后研究员和研究生。会议将在九个会议中分为六个重点领域进行讨论。为期三天的专题讨论会（共六次会议）将锚会议。这些会议的重点将是1。合成碳水化合物化学，2.）糖药物和3.）碳水化合物加工酶的结构/功能研究。此外，还将举行三次为期半天的专题讨论会（三场会议），讨论以下主题：1.碳水化合物结构，2.）构象分析/NMR光谱和3.）糖工程。

DESCRIPTION (provided by applicant): Carbohydrates, particularly those found on cell surfaces, play critical biological roles. For example,glycoconjugates are involved in the development and differentiation of cells, cell adhesion and cell signaling, and cell-matrix interactions. It is also well documented that changes either in the structures of these glycans, or in the expression of carbohydrate-binding proteins, are associated with an ever-increasing number of diseases, include human genetic diseases such as muscular dystrophy or congenital disorders of glycosylation, viral and bacterial infections, parasite invasion and survival as well as metastasis and tumor progression. Recently published studies have demonstrated that glycoconjugates are also regulators of the immune system. The main goal of the Gordon Research Conference (GRC) on Carbohydrates is to bring together a diverse group of scientists who work in the broad area of "glycoscience", a term that, loosely speaking, refers to the fields of carbohydrate chemistry, carbohydrate biochemistry, and glycobiology, to discuss recent progress and future challenges in the field. This meeting, like those held in previous years, will involve individuals with a range of experience, ranging from well-established senior investigators to newcomers to the field, including junior faculty, postdoctoral fellows and graduate students. The meeting will have talks organized into six focus areas in nine sessions. Three full day symposia (a total of six sessions) will anchor the meeting. The focus of these sessions will be 1.) synthetic carbohydrate chemistry, 2.) glycopharmaceuticals and 3.) structure/function studies of carbohydrate processing-enzymes. In addition three half-day symposia (three sessions) will be held on the following topics: 1.) carbohydrate structure, 2.) conformational analysis/NMR spectroscopy and 3.) glycoengineering.