Conference-Pathogenesis of Neuroimmunologic Disease

描述（由申请人提供）：本申请代表了对在马萨诸塞州伍兹霍尔海洋生物实验室提供的题为“神经免疫疾病的发病机制”的短期课程的持续支持的请求。预计2007年、2009年和2011年将每隔一年举办一次培训班。该课程提供了一系列神经和精神疾病的发病机制中的当前概念的全面调查，并包括一个教师，人数约40人，由基础科学家和具有广泛专业知识的医生科学家组成。为期两周的讲座计划将描述遗传，分子和细胞生理学的概念和技术在免疫学和神经生理学中的应用，以分析被认为具有免疫基础的已知神经疾病的发病机制。讲座：基础神经生物学将涵盖细胞，分泌因子，粘附分子，神经系统的生理学和结构;免疫生物学将解决细胞，因子，粘附分子和网络相互作用，表征免疫系统和炎症装置。还将介绍免疫遗传学的基础知识;免疫病理学疾病将通过讨论脱髓鞘疾病来介绍，这将与髓鞘发育不良以及营养和代谢髓鞘疾病进行比较和对比。人类疾病的模型和使用转基因和基因敲除小鼠也将被广泛介绍和讨论;病毒神经发病机制将考虑病毒感染; HIV相关的神经发病机制，细胞因子在中枢神经系统中的作用和细胞因子信号传导到神经细胞。本主题将通过解决巨噬细胞和小胶质细胞在中枢神经系统HIV相关病理学中的作用进行扩展，并详细讨论外周神经系统（包括肌肉）中HIV相关病理学;其他神经系统疾病中的神经炎症将通过下丘脑功能的炎症调节讲座进行介绍，反之亦然。会议将通过在卫生保健机构和相关的病毒和动物自身免疫模型的典型神经免疫疾病患者的演示来补充

DESCRIPTION (provided by applicant): This application represents a request for continued support for a short course entitled "Pathogenesis of Neuroimmunological Diseases" offered at the Marine Biological Laboratory, Woods Hole, MA. It is anticipated that the course will be offered every other year for 2007, 2009 and 2011. The course offers a comprehensive survey of current concepts in the pathogenetic mechanisms involved in a series of neurologic and psychiatric diseases, and includes a faculty, numbering about 40, composed of basic scientists and physician scientists with a wide area of expertise. The two-week program of lectures will describe the application of genetic, molecular, and cell physiologic concepts and techniques in current use in immunology and neurophysiology to the analysis of the pathogenesis of the better known neurologic diseases thought to have an immune basis. Lectures in: Basic Neurobiology will cover cells, secreted factors, adhesion molecules, physiology and structure of the nervous system; Immunobiology will address the cells, factors, adhesion molecules and network interactions that characterize the immune system and inflammatory apparatus. The basics of immunogenetics will also be introduced; Immunopathological disease will be introduced by discussing demyelinating disorders, which will be compared and contrasted with dysmyelinations, as well as nutritional and metabolic myelin diseases. Models of human disease and use of transgenic and knockout mice will also be introduced and discussed extensively; Viral neuropathogenesis will consider viral infections; HIV-related neuropathogenesis, cytokine action in the CNS and cytokine signaling to neural cells. This topic will be extended by addressing the roles of macrophages and microglia in CNS HIV-related pathology, with detailed discussion of HIV-associated pathology in the peripheral nervous system, including muscle; Neuroinflammation in other neurological diseases will be introduced with lectures on inflammatory regulation of hypothalamic function, and, conversely on vagal control of inflammation. The sessions will be supplemented by demonstrations of patients with typical neuroimmunologic disease at health care institutions and of relevant viral and autoimmune models in animals