CORE--ANIMAL MODELS

这一核心的目的是提供一致的动物模型的准备 各种各样的项目。这将是这个核心的责任准备慢性动物模型 个人调查员使用。这将减少准备工作的可变性，并将个别项目主任从创建这些准备工作和照顾其术后立即恢复的极端劳动密集型任务中解放出来。Core还将提供在发生心力衰竭或假时间控制之前和期间动物的超声心动图数据。各种动物模型将由康尼什博士准备或在他的指导下制作，康尼什博士在慢性动物准备方面有多年经验，在这些特定的动物准备方面经验丰富。在动物被各种调查人员使用之前，他将在两名技术人员的协助下准备和照料动物。由该核心制备的模型将是(1)大鼠冠脉结扎心力衰竭(HF)模型和(2)兔心衰起搏模型。在过去几年PPG的发展过程中，使用声学测量晶体来提供与心功能有关的信息已转向使用超声心动图数据。这始于扎克博士实验室的工作，但现在也被其他实验室更普遍地使用。由于只有一台超声心动图机可用，这一功能现在将成为动物核心的一部分。Hallgren-Golka女士将加入Core，主要负责在诱发心力衰竭之前、期间和之后获取关于老鼠和兔子的数据。Hallgren-Golka女士将在Kaye Talbitzer的协助下，为其他项目提供这项服务。

The purpose of this Core is to provide for the consistent preparation of animal models across the various projects. It will be the responsibility of this Core to prepare the chronic animal models for individual investigator use. This will reduce the variability of preparations and will release the individual project directors from the extremely labor intensive task of creating these preparations and caring for their immediate post operative recovery. The Core will also provide echocardiograph data on the animals prior to and during the development of heart failure or sham time controls. The various animal models will be prepared by or under the direction of Dr. Cornish who has had many years of experience in the preparation of chronic animals and is experienced in these specific animal preparations. He will be assisted by two technicians in the preparation and care of the animals prior to their use by the various investigators. The models prepared by this core will be (1) the coronary ligation model of heart failure (HF) in the rat, and (2) the pacing model of HF in the rabbit. During the development of the PPG over the past years, the use of the sonomicrometry crystals for providing information relative to ventricular function has shifted to the use of echocardiographic data. This began with work in Dr. Zucker's laboratory but is now being used more generally by the other labs as well. Since there is only one echocardiogram machine available, this function will now become part of the animal core. Ms. Hallgren-Golka will be joining the Core and has been primarily responsible for obtaining data on rats and rabbits prior to, during and after the induction of heart failure. Ms. Hallgren-Golka, with the assistance of Kaye Talbitzer, will now provide this service to the other projects.