Translational Study of Hostility, Atherothrombosis & CAD

描述（由申请人提供）： 此次K23申请旨在使Daichi Shimbo博士能够发展成为一名独立的、具有预防心脏病学专业知识的转化研究人员。他接受过心脏病学的培训，并在基础科学研究方面有过一些经验，但缺乏一些基本技能，无法成为该领域的独立研究人员。他的短期目标是加强他在临床试验，基础科学和预防心脏病学方面的理论，方法和统计技能。他的长期目标是建立一个由外部资源资助的独立实验室，培训和指导未来的临床研究人员，并建立一个致力于预防心脏病学的研究科学家网络。该奖项将帮助Shimbo博士实现他的短期和长期目标，为他提供时间和资源，以获得以下五个模块的知识和专业知识：（1）临床试验设计，（2）统计学，（3）与以患者为导向的研究相关的基础科学方法，（4）预防心脏病学，（5）医学研究传播。NIH赞助的K30研究课程，综合与行为心脏病学计划和心血管生物学研究实验室使西奈山医学院成为这种培训的理想环境。托马斯皮克林博士是该奖项的理想赞助商，因为他在预防心脏病学方面的专业知识享誉世界。 由于确定的危险因素不能解释所有发生急性冠状动脉综合征（ACS）的患者，因此出现了对“非经典”危险因素的研究。有证据表明，其中一个因素，敌意，独立预测ACS事件。确切的生物学机制的潜在危险性-ACS的联系尚未阐明。炎症和血小板在ACS的发展中起着核心作用，因此敌意可能通过炎症和血小板血栓形成途径增加ACS的风险。拟议研究计划的目标是：（1）检查更高水平的敌意是否与炎症标志物和血小板反应性水平的增加有关;（2）检查敌意减少是否会降低炎症标志物和血小板反应性水平。来自这个转化研究项目的数据将使Shimbo博士能够建立一个经验基础，将这些数据应用于为敌对患者制定有效的预防干预措施。

DESCRIPTION (provided by applicant): This K23 application is a request to enable Dr. Daichi Shimbo to develop into an independent, translational researcher with expertise in preventive cardiology. He has training in cardiology and has had some previous experience in conducting basic science research, but lacks some fundamental skills that would allow him to become an independent researcher in this field. His short-term goals are to strengthen his theoretical, methodological, and statistical skills in clinical trials, in the basic sciences, and in preventive cardiology. His long-term goals are to develop an independent lab funded by external sources, to train and mentor future clinical researchers, and to develop a network of research scientists devoted to preventive cardiology. This award will aid Dr. Shimbo in attaining his short- and long-term goals by providing time and resources for him to acquire knowledge and expertise in the following five modules: (1) clinical trials design, (2) statistics, (3) basic science methodology relevant to patient-oriented research, (4) preventive cardiology, and (5) medical research dissemination. The NIH-sponsored K30 Research Curriculum, the Integrative & Behavioral Cardiology Program, and the Cardiovascular Biology Research Laboratory make Mount Sinai School of Medicine an ideal environment for this training. Dr. Thomas Pickering is an ideal sponsor of this award because of his world-renowned expertise in preventive cardiology. Because established risk factors do not account for all patients who develop the acute coronary syndromes (ACS), the search for "non-classic" risk factors has emerged. Evidence suggests that one such factor, hostility, independently predicts ACS events. The exact biological mechanisms underlying the hostility-ACS link have not been elucidated. Inflammation and platelets play central roles in the development of the ACS, and thus hostility may increase ACS risk through the inflammation and platelet-thrombosis pathways. The goals of the proposed research program are (1) to examine whether higher levels of hostility are associated with increased levels of inflammatory markers and platelet reactivity, and (2) to examine whether hostility reduction decreases levels of inflammatory markers and platelet reactivity. Data from this translational research program will allow Dr. Shimbo to establish an empirical foundation from which to apply these data to the development of effective preventive interventions for hostile patients.