CLINICAL CORE

临床核心（核心B）的主要目标是提供一个特征明确的自闭症和自闭症谱系障碍受试者以及非自闭症对照受试者队列，供GNYARCE研究项目和合作项目招募。核心B将通过诊断评价和共病评估、认知、发育和适应性评估、病史和筛查以及从自闭症和自闭症谱系受试者以及家庭成员和对照/对照受试者（如适用）中采集遗传样本来获取全面的临床和实验室数据。它将收集一组常见的评估数据，并测量目标核心症状领域和相关特征， 合并症，以更好地定义队列。核心将提供基线评价，以评估诊断合格性和认知能力，进行功能分析，并描述纳入项目I、II和III的核心神经病学特征。为了实现其目标，核心B将利用三个临床研究中心和一个遗传研究中心：西奈山医学院的西弗自闭症研究中心、斯托尼布鲁克的纽约州立大学的科迪自闭症和发育障碍中心、北岸-长岛犹太卫生系统的自闭症中心和西奈山的家庭遗传研究项目。

The primary objective of the Clinical Core (Core B) will be to provide a well-characterized cohort of subjects with autism and autism spectrum disorders and non-autistic control subjects for enrollment in GNYARCE research projects and collaborative endeavors. Core B will acquire comprehensive clinical and laboratory data through diagnostic evaluation and assessment of comorbidity, cognitive, developmental, and adaptive assessment, medical history and screening, and genetic sample collection from autistic and autism spectrum subjects as well as family members and control/comparison subjects, as appropriate. It will collect a common set of assessment data and measure target core symptom domains and associated features and comorbid conditions to better define the cohort. The Core will provide baseline evaluation to assess diagnostic eligibility and cognitive ability, perform a functional analysis, and characterize core symptomatology for inclusion in Projects I, II, and III. To accomplish its goals, Core B will utilize three clinical research sites and a genetic research site: the Seaver Autism Research Center at the Mount Sinai School of Medicine, the Cody Center for Autism and Developmental Disabilities at the State University of New York at Stony Brook, the Center for Autism in the North Shore-Long Island Jewish Health System, and the Family Genetic Studies Program at Mount Sinai.