New Non-invasive Method to Detect Myocardial Ischemia

描述（由申请人提供）：检测心肌缺血的新的无创方法-对疑似患有急性冠状动脉综合征（急性心肌梗死或不稳定型心绞痛）的患者进行及时诊断对于患者的短期和长期结局至关重要。常规12导联心电图（ECG）是检测因胸痛或心绞痛等症状到急诊室（艾德）就诊的患者中急性冠状动脉综合征（ACS）的主要诊断工具。不幸的是，传统的心电图缺乏灵敏度，诊断约50%的这些患者。本研究探讨了一种有前途的新的非侵入性缺血检测方法，可以提高心电图的诊断率。数字信号处理技术用于揭示ECG去极化波（HF-QRS）的细微、高频、低振幅分量。研究表明，HF-QRS分量检测可以将缺血检测的灵敏度和特异性提高多达5- 15%。将对来自前瞻性临床试验的高分辨率24小时霍尔特数据进行二次分析，以比较常规ECG与HF-QRS检测缺血的灵敏度和特异性。

DESCRIPTION (provided by applicant): New Non-invasive Method to Detect Myocardial Ischemia-The timely diagnosis of patients suspected of having Acute Coronary Syndromes (acute myocardial infarction or unstable angina) is crucial to favorable short- and long-term patient outcomes. The conventional 12-lead electrocardiogram (ECG) is the primary diagnostic tool for the detection of Acute Coronary Syndromes (ACS) in patients presenting to the Emergency Department (ED) with chest pain or anginal equivalents. Unfortunately, the conventional ECG lacks sensitivity to diagnose approximately 50% of these patients. The purposed research examines a promising new non-invasive method of ischemia detection which could improve the diagnostic yield of the electrocardiogram. Digital signal processing techniques are used to uncover subtle, high frequency, low amplitude, components of the ECG depolarization wave (HF-QRS). Studies show that HF-QRS component detection may improve the sensitivity and specificity of ischemia detection by as much as 5-15%. A secondary analysis of high resolution, 24-hour Holter data from a prospective clinical trial will be conducted to compare sensitivity and specificity of conventional ECG versus HF-QRS in the detection of ischemia.