Improved methods for perfusion imaging

描述（由申请人提供）：定量灌注主要受到脑血容量（CBV）测量不准确的影响。这是由于部分体积伪影和对造影剂浓度响应的非线性的结合。方法将开发获得一个独立的全脑测量CBV与造影剂输注技术。我们最近为我们机构的MRI扫描仪购买了SENSE硬件和软件，因此将修改灌注脉冲序列以利用SENSE来减少图像中的敏感性伪影，将在正常受试者中使用统计参数映射（SPM）技术开发血流量和体积测量的后处理。每个受试者的3D脑血流量（CBF）和CBV图将被共同登记到一个共同的脑图谱中，并编制一个正常灌注和血容量数据库。一旦这些方法得到实施，这些技术将扩展到诊断为痴呆症的患者的研究。具体来说，CBF和CBV将使用ROI和逐体素统计分析（如SPM）将其与年龄和性别匹配的对照组进行比较。

DESCRIPTION (provided by applicant): Quantitative perfusion is primarily hampered by inaccuracies in measurements of cerebral blood volume (CBV). This is due to a combination of partial volume artifact and nonlinearity in the response to contrast agent concentration. Methods will be developed to obtain an independent whole brain measurement of CBV with a contrast infusion technique. We have recently purchased SENSE hardware and software for the MRI scanners at our institution so will modify the perfusion pulse sequence to take advantage of SENSE to reduce susceptibility artifacts in our images, Post-processing of blood flow and volume measurements will be developed using Statistical Parametric Mapping (SPM) techniques in normal subjects. Each subject's 3D cerebral blood flow (CBF) and CBV map will be coregistered to a common brain atlas, and a database of normal perfusion and blood volume will be compiled. Once these methods are implemented, these techniques will be extended to the study of patients with diagnosed dementias. Specifically, CBF and CBV will be compared to age and gender matched controls using both ROI and voxel by voxel statistical analyses such as SPM.