DIABETES PREVENTION PROGRAM - OUTCOMES STUDY (DPP-OS)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 参与糖尿病预防计划(DPP)的受试者将被跟踪评估他们的长期结果。所有受试者都在DPP期间的基础上接受了改良的生活方式干预。我们希望继续检验这一假说，即从IGT到2型糖尿病的进展可以通过密集的生活方式改变或二甲双胍来预防或延缓，并评估这些干预措施对选定的个体健康结果的影响，包括心血管疾病和危险因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Subject who participated in the Diabetes Prevention Program (DPP) will be followed to assess their long-term outcomes. All subjects were offered a modified lifestyle intervention based on that offered during the DPP. We wish to continue to test the hypothesis that progression from IGT to type 2 diabetes can be prevented or delayed by intensive lifestyle modification or metformin and to evaluate the effects of these interventions on selected inividual health outcomes, including cardiovascular disease adn risk factors.