SEX-RELATED DETERMINANTS OF PAIN RESPONSES IN FIBROMYALGIA-FAMILY STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项调查的总体目的是为了更好地了解一致的发现，即患有纤维肌痛(FM)的女性的一级亲属比没有纤维肌痛或其他以持续性疼痛为特征的疾病的健康女性的一级亲属更经常符合ACR的纤维肌痛标准和DSM-IV的情绪障碍标准。为了实现这一目标，我们建议研究(A)符合ACR纤维肌痛标准的成年女性(FM先证者)；(B)没有FM或任何其他以持续性疼痛为特征的疾病的成年健康对照组女性；以及(C)每个FM先证者和健康对照组女性的一个兄弟姐妹。我们还建议从FM先证者、健康对照组和他们的兄弟姐妹那里获得三组数据。这些数据涉及(A)对机械压力刺激、热刺激和缺血(次最大努力止血带)刺激的疼痛敏感性；(B)用于检测血清5-羟色胺水平和产生基因组DNA样本的血液样本；以及(C)对结构化精神病学访谈的反应(即诊断性访谈时间表)和心理社会变量的标准化测量(例如，流行病学研究中心抑郁量表；Kohn反应性量表)。我们建议使用这些数据来测试7个假说，这些假说来自我们的FM病因模型，关于FM家族史与性别相关的疼痛敏感性增强的程度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this investigation is to better understand the consistent finding that first-degree relatives of women with fibromyalgia (FM) more frequently meet the ACR criteria for fibromyalgia and DSM-IV criteria for mood disorders than the first-degree relatives of healthy women without fibromyalgia or other disorders characterized by persistent pain. In order to achieve this aim, we propose to study (a) adult women who met ACR criteria for fibromyalgia (FM proband); (b) adult, healthy control women without FM or any other disorder characterized by persistent pain; and (c) one sibling of each FM proband and healthy control woman. We also propose to obtain three sets of data from the FM probands, healthy controls, and their siblings. These are data regarding (a) pain sensitivity in response to mechanical pressure stimulation, thermal heat stimulation, and ischemic (submaximun effort tourniquet) stimulation; (b) blood samples used to assay serum serotonin levels and produce genomic DNA samples; and (c) responses to a structured psychiatric interview (i.e., Diagnostic Interview Schedule) and standardized measures of psychosocial variables (e.g., Center for Epidemiological Studies-Depression scale; Kohn Reactivity Scale). We propose to use these data to test 7 hypotheses, derived from our model of the etiopathogenesis of FM, regarding the extent to which family history of FM is associated with enhanced pain sensitivity in a sex-dependent manner.