SOY AND METABOLISM IN MENOPAUSE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 理论基础：更年期与胰岛素抵抗的增加有关。雌激素替代疗法可能会改善胰岛素抵抗。自从《妇女健康倡议》的研究结果发表以来，妇女正在停止激素替代疗法，并开始接受大豆植物雌激素等替代疗法，尽管其预防疾病的有效性的证据有限。 假设：我们的总体假设是，饮食中补充大豆植物雌激素通过增加绝经后肥胖女性的葡萄糖处置和减少胰岛素分泌来改善葡萄糖代谢，而与身体成分的变化无关。 实验方法：总共70名妇女将被招募参加为期3个月的随机、双盲、安慰剂对照研究。女性将被随机分为：1)复活大豆奶昔(16克大豆蛋白和120毫克异黄酮类)，或2)安慰剂(酪蛋白)奶昔。在基线和3个月时，我们将使用低血糖钳夹方法测量葡萄糖代谢和胰岛素分泌，并使用计算机断层扫描和双能X射线吸收法测量身体成分。 意义：本研究将为大豆补充植物雌激素对绝经后肥胖妇女糖代谢的影响提供新的认识，这将对临床护理产生影响。此外，我们的发现将为人类补充大豆植物雌激素和葡萄糖代谢的生理机制提供新的知识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rationale: Menopause has been associated with increased insulin resistance. Estrogen replacement may improve insulin resistance. Since the publication of the Women's Health Initiative findings, women are discontinuing hormone replacement therapy and starting alternative treatments such as soy phytoestrogens, despite limited evidence for their efficacy in disease prevention. Hypothesis: Our overall hypothesis is that dietary supplementation with soy phytoestrogens improves glucose metabolism by increasing glucose disposal and reducing insulin secretion in obese postmenopausal women, independently of changes in body composition. Experimental approach: A Total of 70 women will be recruited for the 3-month randomized, doubleblinded, placebo-controlled study. Women will be randomized to: 1) Revival Soy shakes(l6 grams of soy protein and 120 mg isoflavones), or 2) placebo (casein) shakes daily. At baseline and 3 months, we will measure glucose disposal and insulin secretion using hypaglycemic clamp methodology, and body composition using computer tomography and dual energy x-ray absorptiornetry. Significance: This study will provide new knowledge on the effects of soy phytoestrogen supplementation on glucose metabolism in obese postmenopausal women which will impact on clinical care. In addition, our findings will provide new knowledge of physiologic mechanisms involved with soy phytoestrogen supplementation and glucose metabolism in humans.