Memory Binding in the Mammalian Hippocampus

描述（由申请人提供）：项目摘要：本提案的总体目标是通过追求严格的研究项目，最初在记忆研究领域的领导者霍华德Eichenbaum博士的指导下，为候选人作为独立科学家的职业生涯做好准备。该研究项目的目标是了解海马和海马旁区的回路，这些回路支持空间和非空间信息在陈述性记忆服务中的结合。该项目利用了候选人在记忆研究方面的广泛经验，包括对大鼠的电生理研究和对健忘症患者的研究。在项目期间，候选人将获得先进的记录技术，计算建模，教学，拨款写作和实验室管理技能的基本培训。该项目将使候选人能够实现他的近期目标（在一所主要的研究型大学获得终身教职）和长期目标（建立一个尖端记忆研究项目，包括在人类和实验动物中的工作）。相关性：海马体记忆系统支持对个人事件和世界知识的记忆，提供对心理健康至关重要的自我意识。靶向海马体的疾病是普遍的（例如，痴呆症、阿尔茨海默氏病）以及有关健康海马记忆系统基本功能的知识对于理解记忆障碍至关重要。

DESCRIPTION (provided by applicant): Project Summary: The overall goal of this proposal is to prepare the candidate for a career as an independent scientist by pursuing a rigorous research project initially under the mentorship of a leader in the field of memory research, Dr. Howard Eichenbaum. The goal of the research project is to understand the circuitry in the hippocampal and parahippocampal regions that supports binding of spatial and nonspatial information in the service of declarative memory. The project takes advantage of the candidate's broad experience in memory research and includes electrophysiological studies in rats and studies with amnesic patients. During the project, the candidate will acquire essential training in advanced recording techniques, computational modeling, teaching, grant writing, and laboratory management skills. The project will enable the candidate to reach his immediate goals (secure tenure-track employment at a major research university) and long-term goals (establish a program of cutting-edge memory research that includes work in both humans and experimental animals). Relevance: The hippocampal memory system supports memory for personal events and knowledge about the world, providing a sense of self that is essential to mental health. Diseases that target the hippocampus are prevalent (e.g., dementia, Alzheimer's disease), and knowledge about the fundamental function of the healthy hippocampal memory system will be crucial for understanding memory disorders.