A Compact X-ray Station for Protein Crystallography

此快速通道SBIR的目的是开发一种创新的紧凑型X射线站(CXS)，用于 大分子结晶学。该站接受紧凑型光的输出X射线束 源是一个微型同步加速器，向三个终端站提供X射线束。每条光束线 配备一个集成的商用衍射仪。两个侧站中的每一个都接收一个 30微米RMS光斑中的可调谐单色X射线束。前转站接收到 聚焦的高通量窄带X射线束。每个x射线束在7到16 kev范围内可调。 并将提供可与同步加速器光束线相媲美的通量和能量分辨率。光束线 可以单独运行，成对运行，也可以同时运行。在第一阶段，我们将设计x射线 光学系统，并实验测试一种新型的可调谐聚焦单色器。在第二阶段，我们 将建造x射线光学元件和终端站，集成商业衍射仪，并全面测试 终端站。CXS是一个创新的、强大的、‘交钥匙’X射线系统，它将提供一个家 用于大分子结晶学的三条同步加速器光束线实验室；两条光束线 将具有单波长或多波长异常的通量、可调性和能量分辨率 色散实验，第三条光束线将进行优化，以实现更高通量的筛选。

The purpose of this Fast-Track SBIR is to develop an innovative Compact X-ray Station (CXS) for macromolecular crystallography. This station accepts the output x-ray beam of the Compact Light Source, a miniature synchrotron, and delivers x-ray beams to three endstations. Each beamline accommodates an integrated commercial diffractometer. Each of two side stations receives a tunable, monochromatic x-ray beam in a 30 micron rms spot. The forward station receives a focused higher-flux narrow band x-ray beam. Each of the x-ray beams is tunable from 7 to 16 keV and will provide a flux and energy resolution comparable to synchrotron beamlines. The beamlines can be run separately, in pairs or all three simultaneously. In Phase I, we will design the x-ray optics systems and experimentally test a new,tunable focusing monochromator. In Phase II, we will build the x-ray optics and end stations, integrate a commercial diffractometer and fully test the endstations. The CXS is an innovative, powerful, 'turn key'x-ray system which will provide a home laboratory with three 'synchrotron' beamlines for macromolecular crystallography; two beamlines will have the flux, tunability, and energy resolution for single- or multi-wavelength anomalous dispersion experiments, and the third beamline will be optimized for higher-flux screening.