Catheters Designed for Decreased Clotting and Infection

描述（由申请人提供）：本研究的目标是制造一种血管内双功能导管，可防止凝血和感染。这将通过将新型硒（Se）化学物质与表面结合肝素结合来实现。该I期申请的目标是开发将Se复合物掺入导管聚合物中的制造工艺，将肝素固定在导管表面，并评价器械的体外抗菌和抗血小板功能。具体而言，目标是：1。使用两种制造方法设计具有抗血栓形成和抗菌性能的生物相容性中心静脉导管。2.比较制造方法以最大化功能3.对涂层导管进行初步抗菌和抗血小板试验。这种方法在改善导管的生物相容性设计特征方面是一个重大进步，因为它模拟了内皮细胞生物化学中存在的基于Se的催化化学。通过减少凝血和感染，该技术将同时延长导管寿命并降低患者发病率。目前感染或凝结的导管必须被移除和更换，导致医疗保健成本增加和患者风险增加。这些设备在现代医疗保健中无处不在的性质表明这种创新技术具有巨大的潜在市场。这项资助的目标是制造一种血管内双功能导管，既能防止凝血又能防止感染。通过减少凝血和感染，该技术将同时增加导管的寿命并减少患者死亡。目前感染或凝结的导管必须被移除和更换，导致医疗保健成本增加和患者风险增加。

DESCRIPTION (provided by applicant): The goal is this study is to fabricate an intravascular dual-functioning catheter that prevents both clotting and infection. This will be accomplished by combining novel selenium (Se) chemistries with surface bound heparin. The goals of this phase I application are targeted at developing the manufacturing processes for incorporating the Se-complexes into the polymer of the catheter, immobilizing heparin on the surface of the catheter, and evaluating the in vitro antimicrobial and antiplatelet function of the device. Specifically, the aims are: 1. Design a biocompatible central venous catheter with antithrombotic and antimicrobial properties using two fabrication methods. 2. Compare the fabrication methods to maximize functionality 3. Conduct preliminary antimicrobial and antiplatelet assays with the coated catheters. This approach is a significant advance in improving the biocompatibility design features of catheters, as it mimics a Se-based, catalytic chemistry present in endothelial cell biochemistry. By decreasing clotting and infection, this technology will simultaneously increase catheter longevity and decrease patient morbidity. Currently infected or clotted catheters have to be removed and replaced leading to increased health care costs and increased risks to patients. The ubiquitous nature of these devices in modern health care suggests a vast potential market for this innovative technology. The goal in this grant is to make an intravascular dual-functioning catheter that prevents both clotting and infection. By decreasing clotting and infection, this technology will simultaneously increase the life- time of the catheter and decrease patient death. Currently infected or clotted catheters have to be removed and replaced leading to increased health care costs and increased risks to patients.