NIH Biotechnologist: Authentic Exploration of Biotechnology in Health Science

描述（由申请人提供）：拟议的NIH生物技术专家：健康科学中生物技术、遗传学和基因组学的真实探索项目将产生一个模型课程——“限制性酶切图谱：绘制质粒上的限制性酶切位点”——源自非营利性教育图像处理中心开发的生物技术专家教学材料。作为高中和大学教学的补充活动，本课程将使用Wiggins和McTighe（2005）的设计理解方法进行重组；更新与美国国立卫生研究院（NIH）使命相关的当前内容材料；通过促进教师可定制性和学习者互动性的技术加强；并打包成电子学习格式，以方便测试并提高教师和学生的可用性。本课程将以一种吸引人的方式向学习者介绍限制映射，提供在线工具，允许学习者通过进行基础科学实验来探索主题，分析实验期间收集的数据，反思他们所学到的知识，并将他们的发现与发现类似知识的叙述结合起来。该课程将作为一套完整教材的原型，这套教材将在SBIR第二阶段赠款的资助下开发。Biotechnologist的更新、改进和重新利用将由营利性公司Science Approach进行。该项目将完成以下里程碑：(1)通过更新、改进和重新利用生物技术专家现有的“限制性酶切图谱：在质粒上绘制限制性酶切位点”课程，开发一个NIH生物技术专家的模型课程；(2)由高中教师、大学教师和本科生组成的小组对模型课进行试点测试，以发现可用性问题，找出成功实施教材的障碍，并获得关于模型课和计划教材集的反馈；(3)对试点测试数据进行分析，将示范课修改为第二阶段全套教学材料的模板；(4)最终确定全套NIH Biotechnologist材料的目录；(5)通过探索与国家科学教师协会的关系，评估NIH生物技术专家的合作开发、营销和分配渠道；(6)在第二阶段SBIR项目中制定开发和实地测试全套教学材料的计划。通过让学生沉浸在NIH支持的研究的真实研究数据中，NIH生物技术专家项目将(1)有助于促进具有科学素养的公众的发展，使其能够发扬为美国提供高水平生活的科学和技术的天赋；(2)向学习者介绍NIH支持的生物技术、遗传学和基因组学研究在改善生物医学诊断、治疗和研究方面所起的关键作用。拟议的NIH生物技术专家：健康科学中生物技术、遗传学和基因组学的真实探索项目将涉及高中和本科生学习生物技术、遗传学和基因组学。拟议的教学材料不仅强调了NIH支持的研究在提高生物医学诊断、治疗和研究方面所起的关键作用，NIH生物技术专家还将促进科学素养公众的发展，使其能够发扬使美国成为生物医学领域领导者的科学和技术的天赋，并为其公民提供国家享有的高水平生活。

DESCRIPTION (provided by applicant): The proposed NIH Biotechnologist: Authentic Explorations of Biotechnology, Genetics, and Genomics in Health Science project will produce a model lesson-"Restriction Mapping: Mapping restriction sites on a plasmid"-derived from the Biotechnologist instructional materials developed by the nonprofit Center for Image Processing in Education. Designed to be a supplementary activity for high school and college instruction, the lesson will be restructured using the Understanding by Design methodology of Wiggins and McTighe (2005); updated with current content material relevant to the mission of the National Institutes of Health (NIH); enhanced with technologies that promote customizability by instructors and interactivity for learners; and packaged in an eLearning format to facilitate testing and improve its usability for instructors and students. The lesson will introduce the learner to restriction mapping in an engaging manner, provide online tools that allow the learner to explore the topic by conducting a basic science experiment, analyze data gathered during the experiment, reflect on what they have learned, and integrate their discoveries with narrative accounts of the discovery of similar knowledge. The lesson will serve as a prototype for a full set of materials to be developed with funding from a Phase II SBIR grant. Updating, improvement, and repurposing of Biotechnologist will be conducted by Science Approach, a for-profit corporation. The project will accomplish the following milestones: (1) develop a model NIH Biotechnologist lesson by updating, improving, and repurposing the existing "Restriction Mapping: Mapping restriction sites on a plasmid" lesson from Biotechnologist; (2) pilot test the model lesson with a panel of high school teachers, college instructors, and undergraduate students to uncover usability issues, identify barriers to successful implementation of the materials, and receive feedback about the model lesson and planned set of materials; (3) analyze the pilot test data and revise the model lesson into a template for the full set of instructional materials to be produced in Phase II; (4) finalize a table of contents for the full set of NIH Biotechnologist materials; (5) Evaluate channels for collaborative development, marketing, and distribution of NIH Biotechnologist by exploring a relationship with the National Science Teachers Association; and (6) create a plan for developing and field-testing the full set of instructional materials during a Phase II SBIR project. By immersing students in real research data from NIH-supported research, the NIH Biotechnologist project will (1) help promote development of a scientifically literate public that can carry forward the endowment of science and technology that has provided the United States with its high standard of living and (2) introduce learners to the key role that NIH-supported research in biotechnology, genetics, and genomics plays in improving biomedical diagnoses, treatments, and research. The proposed NIH Biotechnologist: Authentic Explorations of Biotechnology, Genetics, and Genomics in Health Science project will involve high school and undergraduate students in learning about biotechnology, genetics, and genomics. Not only will the proposed instructional materials highlight the key role that NIH-supported research plays in improving biomedical diagnoses, treatments, and research, NIH Biotechnologist will promote development of a scientifically literate public that can carry forward the endowment of science and technology that has made the United States a leader in the field of biomedicine and provided its citizens with the high standard of living the nation enjoys.