MEMS Blood Pressure Sensor for a Pediatric VAD

描述（由申请人提供）：每年约有30,000例先天性心脏病（CHD）新病例发生，每年死亡率为5,000至6,000例。这些患者中至少有20%死于围手术期心衰、进行性心肌病（CM）或心脏移植后的并发症。其中，每年有1000至1200名儿科患者是我们的PediaFlowTM心室辅助装置（PVAD）的候选患者。该项目旨在通过开发嵌入泵流入壁上的微型压力传感器，实现PediaFlowTM的舒张末期压力控制。该压力传感器集成了许多创新，包括：动态平衡硅谐振器，通过使用永磁体耦合概念的无连接器组件，以及脉冲激励和信号处理方法。这些创新将导致一种低成本的密封2mm级压力传感器，满足上述需求，并适用于心导管患者和其他手术候选人。用于儿科VAD的MEMS血压传感器主要研究者：Brink， Damon项目叙述血压的测量对许多循环系统疾病的持续治疗至关重要。任何成千上万的心脏手术患者，特别是使用心室辅助装置（vad）的患者，特别是婴儿，都需要几乎持续的监测。该项目采用新的机电系统（MEMS）技术，使软件算法和临床医生能够轻松跟踪血压波动。

DESCRIPTION (provided by applicant): Approximately 30,000 new cases of congenital heart disease (CHD) occur each year with an annual mortality rate of 5,000 to 6,000 patients. At least 20% of these patients die due to perioperative ventricular failure, progressive cardiomyopathy (CM) or complications following cardiac transplants. Of those, 1,000 to 1,200 pediatric patients per year represent the candidates for our PediaFlowTM Ventricular Assist Device (PVAD). This project aims to enable end-diastolic pressure control for the PediaFlowTM by developing a miniature pressure sensor to be embedded in the pump inflow wall. This pressure sensor incorporates a number of innovations including: a dynamically-balanced silicon resonator, connector-less assembly through the use of a permanent magnet coupling concept, and a pulsed approach to excitation and signal processing. These innovations will lead to a low-cost hermetically-sealed 2mm-scale pressure sensor which meets the above need as well as being applicable to cardiac catheterized patients and other surgical candidates. MEMS Blood Pressure Sensor for a Pediatric VAD Principal Investigator: Brink, Damon Project Narrative The measurement of blood pressure is critical to the ongoing treatment of many circulatory ailments. Any of the thousands of cardiac surgery patients, in particular patients utilizing ventricular assist devices (VADs), especially infants, require nearly constant monitoring. This project applies new electromechanical systems (MEMS) technology to enable software algorithms and clinicians to easily track fluctuations in blood pressure.