University of Houston Drug Abuse Research Development Program

描述(由申请人提供)： 休斯顿大学药物滥用研究发展计划(UHDARDP)将提高休斯顿大学(UH)少数族裔教职员工和研究生开展药物滥用竞争研究的能力。这将通过发展多学科基础设施来实现，该基础设施侧重于在老年墨西哥裔美国男性中注射海洛因的长期健康和社会后果。这项研究将对药物滥用的预防、干预和服务的理论和实践具有一定的指导意义。具体目标包括：1)建立机构研究发展计划，通过整合资源、领导、管理和研究专业知识，建设从事竞争性药物研究的能力；2)提供概念、方法和统计支持的结构，以培养少数群体项目主任和研究生；3)执行由一个主要研究项目和两个试点项目组成的多学科研究计划；4)从华盛顿大学招聘其他少数群体项目主任和研究生，以开展对目标人群滥用药物的健康、社会、药理学和心理后果的研究，并向社区提供研究经验和科学信息；5)通过开发关于药物滥用的多学科翻译研究课程、课程和讲习班，弥合社会科学和药学在基础研究和应用研究领域以及服务提供系统之间的差距；以及6)招募一支来自跨学科学术背景的内部和外部导师和顾问团队，以加强UHDARDPS的专业发展活动和拟议的科学方案。提出了免费核心活动的组织基础设施：院校研究发展计划、教师/项目主任发展计划、初级和试点研究项目以及学生发展计划。研究项目将使用为主要研究项目招募的三组老年墨西哥裔美国海洛因使用者(曾经接受治疗、曾经没有接受治疗和现在注射吸毒者)的样本(N=225)。初步研究项目考察了这一人群中的毒品职业、家庭轨迹和成熟过程与多种健康结果和社会资本中介因素的关系。第一个试点将开发一个群体药代动力学模型来描述和预测庆大霉素在该人群中的处置(N=50)。第二个试点将使用“网络促进”模式，重点放在社交网络促进(或阻碍)注射吸毒和相关危险行为的程度(N=60)。

DESCRIPTION (provided by applicant): The University of Houston Drug Abuse Research Development Program (UHDARDP) will increase the capacity of minority faculty and graduate students from the University of Houston (UH) to conduct competitive research on drug abuse. This will be accomplished through the development of a multidisciplinary infrastructure that focus on long-term health and social consequences of injecting heroin use among aging Mexican American males. The research will have implications for drug abuse prevention, intervention, and service theory and practice. Specific aims include: 1) Establish an institutional research development plan to build the capacity to engage in competitive drug research by coalescing resources, leadership, management, and research expertise; 2) Provide a structure for the conceptual, methodological and statistical support to develop minority project directors and graduate students; 3) Execute a multidisciplinary research program consisting of a primary research project and two pilot projects; 4) Recruit other minority project directors and graduate students from UH to develop studies on the health, social, pharmacological and psychological consequences of drug abuse among the target population and provide research experience and scientific information to the community; 5) Bridge the gap between the social and pharmacy sciences in the fields of basic and applied research, and service delivery systems through the development of multidisciplinary translational research courses, curricula and workshops on drug abuse; and 6) Recruit a team of internal and external mentors and consultants from interdisciplinary academic backgrounds to enhance UHDARDPs professional development activities and proposed scientific programs. An organizational infrastructure of complimentary core activities is proposed: Institutional Research Development Plan, Faculty/Project Directors Development Plan, Primary and Pilot Research Projects and a Student Development Plan. The research projects will use a sample of three comparison groups of aging Mexican American heroin users (former in treatment, former not in treatment and current IDU) recruited for the primary research project (N=225). The primary research project examines the drug career, family trajectories and maturing out process in this population in relation to multiple health outcomes and social capital mediators. The first pilot will develop a population pharmacokinetic model to describe and predict the disposition of gentamicin in this population (N=50). The second pilot will use a "network facilitation" model and focus on the extent to which social networks facilitate (or impede) injecting drug use and related risk behaviors (N=60).