Epidemiologic and Basic Science in Cancer Prevention

描述(由申请人提供)：我们在罗斯威尔公园癌症研究所(RPCI)的癌症预防愿景将“板凳到床边”的转化研究范式扩展到“板凳到人行道”模式，整合了基础板凳、流行病学和人口学。我们认为，与癌症治疗一样，预防也需要基础科学的转化。 这个R25T项目的目标是教授四名博士后研究员在癌症预防研究中的跨学科协作能力，该项目的基础是RPCI的癌症预防和人口科学部，该项目的模式是从板凳到人行道。招聘将来自流行病学、人类学、生物化学、遗传学、分子生物学、医学、护理和病理学等领域。潜在研究员将保持其核心学科的基础，同时超越这些学科，建立跨学科合作。这将通过开发专门的课程、其他教学经验和深入研究来实现。为了鼓励学科的并列，学员将与一名主要导师和一名或多名二级导师在不同于主要导师和学员的学科中工作，但与主要导师和学员的学科相互补充。一名学员将在01年招聘，以获得为期三年的奖学金。该计划将由RPCI负责癌症预防和人口科学的高级副总裁詹姆斯·马歇尔博士领导。 该计划建立在RPCI现有优势的基础上：多学科合作的成熟历史；拥有众多资助研究项目的强大导师团队；以及与布法罗大学的合作关系。RPCI的高度跨学科的癌症预防计划由流行病学家、营养学家、基础科学家和医生组成，他们在计划内和越来越多的计划间合作方面有着良好的记录。这一培训计划得到了教师的坚定承诺，将为来自不同科学学科的学员提供机会，利用流行病学、遗传学、生物化学和细胞生物学、癌症发生、化学预防和临床科学方面的广泛专业知识。我们将开发的合作模式是流行病学家/社会科学家Pi博士与生物化学家/分子生物学家Co-Pi博士Clement Ip之间的合作。

DESCRIPTION (provided by applicant): Our vision of cancer prevention at Roswell Park Cancer Institute (RPCI) extends the "bench to bedside" paradigm of translational research to a "bench to sidewalk" model integrating basic bench, epidemiologic and population sciences. We maintain that prevention demands the translation of basic science as much as cancer treatment does. The goal of this R25T program, based in the division of Cancer Prevention and Population Sciences at RPCI, is to teach four postdoctoral fellows to develop the ability for interdisciplinary collaboration in cancer prevention research based on the "bench to sidewalk" model. Recruitment will be from fields such as epidemiology, anthropology, biochemistry, genetics, molecular biology, medicine, nursing and pathology. Potential fellows will maintain grounding in their core disciplines while reaching beyond those disciplines to forge interdisciplinary collaborations. This will be achieved through the development of a specialized curriculum, other didactic experiences, and in-depth research. To encourage this juxtaposition of disciplines, trainees will work with a primary mentor and one or more secondary mentors in a discipline distinct from but complimentary to that of the primary mentor and trainee. One trainee will be recruited in Year 01 for a three year fellowship. The program will be under the leadership of James Marshall, PhD, the Senior Vice President for Cancer Prevention and Population Sciences at RPCI. This program builds on RPCI's existing strengths: an established history of multidisciplinary collaboration; a strong group of mentors with numerous funded research projects; and a collaborative relationship with the University at Buffalo. The highly interdisciplinary Cancer Prevention program at RPCI is comprised of a diverse group of epidemiologists, nutritionists, basic scientists, and physicians with a strong record of intra-programmatic, and increasingly inter-programmatic, collaboration. This training program, with strong commitment from the faculty, will provide trainees from disparate scientific disciplines the opportunity to take advantage of broad-based expertise in epidemiology, genetics, biochemistry and cell biology, carcinogenesis, chemoprevention, and clinical science. A model for the collaboration we will develop is that between the epidemiologist/social scientist PI, Dr. Marshall, and the biochemist/molecular biologist Co-PI, Dr. Clement Ip.