Epidemiologic and Basic Science in Cancer Prevention

描述(由申请人提供)：本提案是为了响应NOT-OD-09-058，标题为“NIH宣布恢复法资金可用于竞争性修订申请”而提交的。我们建议扩大我们由NCI R25T资助的预防博士后培训计划，增加一名能够在两年内完成该计划的实习生。我们的项目现在是满负荷的，有四名博士后研究员；三名是人口科学家，一名是基础科学家。第五名受训人员将是一名基础科学家，他/她可以利用他/她在化学预防和生物标记物领域的专业知识和人脉，同时发展行为、营养和/或社会科学的研究技能。 我们在罗斯威尔公园癌症研究所(RPCI)对癌症预防的愿景来自于将“长凳到床边”的翻译研究范式延伸。在癌症预防和人口科学(CPPS)高级副总裁詹姆斯·马歇尔博士的领导下，该中心已扩展为集基础板凳、临床、流行病学和人口科学于一体的“板凳到人行道”模式。在这一愿景中，预防和癌症治疗一样需要基础科学的转化。预防还要求基础科学--遗传学、生物化学和分子生物学--与预防科学--流行病学和人口科学--相结合。 我们的培训计划以CPPS为基础，以罗斯威尔公园的优势为基础：多学科合作的成熟历史；拥有众多资助研究项目的强大导师团队；以及与布法罗大学的合作。所要求的修订将利用我们现有计划的基础设施，为另一名基础科学家配备癌症预防研究所需的原理、方法和实践。我们的综合培训计划鼓励和支持创新的跨学科研究和专业发展。 拟议的修订将通过雇用一名为期两年的博士后研究员并通过培训该研究员开始独立的研究生涯，来满足复苏法案创造就业机会和加快科学研究步伐的目标。

DESCRIPTION (provided by applicant): This proposal is being submitted in response to NOT-OD-09-058, titled "NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications." We propose to expand our NCI R25T funded postdoctoral training program in prevention with the addition of one trainee capable of completing the program in two years. Our program is now at full capacity with four postdoctoral fellows; three are population scientists and one is a basic scientist. The fifth trainee will be a basic scientist who can use his/her expertise and contacts in the areas of chemoprevention and biomarkers while developing research skills in the behavioral, nutritional and/or social sciences. Our vision of cancer prevention at Roswell Park Cancer Institute (RPCI) is drawn from extending the "bench to bedside" paradigm of translational research. Under the leadership of James Marshall, PhD, Senior Vice President for Cancer Prevention and Population Sciences (CPPS), it has been broadened into a "bench to sidewalk" model, integrating basic bench, clinical, epidemiologic and population sciences. In this vision, prevention demands the translation of basic science as much as cancer treatment does. Prevention also requires that the basic bench sciences -- genetics, biochemistry and molecular biology -- be integrated with the sciences of prevention: epidemiology and population sciences. Our training program, based in CPPS, builds on Roswell Park's strengths: an established history of multidisciplinary collaboration; a strong group of mentors with numerous funded research projects; and collaboration with the University at Buffalo. The requested revision will use the infrastructure of our existing program to equip an additional basic scientist with the principles, methods and practices needed for cancer prevention research. Our comprehensive training program encourages and supports innovative transdisciplinary research and professional development. The proposed revision will meet the Recovery Act objectives of job creation and accelerating the pace of scientific research by employing a postdoctoral fellow for two years and by training that fellow to launch an independent research career.