Epidemiologic and Basic Science in Cancer Prevention

癌症预防的流行病学和基础科学

• 批准号: 7811211
• 负责人: James Marshall
• 金额: $ 24.84万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7811211
• 关键词: Applications Grants; Area; Basic Science; Behavioral; Biochemistry; Biological Markers; Buffaloes; Chemoprevention; Clinical; Collaborations; Development; Discipline; Doctor of Philosophy; Epidemiology; Faculty; Funding; Goals; Interdisciplinary Study; Leadership; Link; Marshal; Mentors; Methods; Modeling; Molecular Biology; Nutritional; Occupations; Population; Population Sciences; Positioning Attribute; Postdoctoral Fellow; Prevention; Prevention Research; Program Reviews; Recording of previous events; Recovery; Research; Research Infrastructure; Research Project Grants; Role; Roswell Park Cancer Institute; Science; Science of genetics; Scientist; Social Sciences; Training; Training Programs; Translational Research; Translations; United States National Institutes of Health; Universities; Vision; base; bench to bedside; cancer prevention; cancer therapy; career; experience; innovation; meetings; post-doctoral training; programs; response; skills

DESCRIPTION (provided by applicant): This proposal is being submitted in response to NOT-OD-09-058, titled "NIH Announces the Availability of Recovery Act Funds for Competitive Revision Applications." We propose to expand our NCI R25T funded postdoctoral training program in prevention with the addition of one trainee capable of completing the program in two years. Our program is now at full capacity with four postdoctoral fellows; three are population scientists and one is a basic scientist. The fifth trainee will be a basic scientist who can use his/her expertise and contacts in the areas of chemoprevention and biomarkers while developing research skills in the behavioral, nutritional and/or social sciences. Our vision of cancer prevention at Roswell Park Cancer Institute (RPCI) is drawn from extending the "bench to bedside" paradigm of translational research. Under the leadership of James Marshall, PhD, Senior Vice President for Cancer Prevention and Population Sciences (CPPS), it has been broadened into a "bench to sidewalk" model, integrating basic bench, clinical, epidemiologic and population sciences. In this vision, prevention demands the translation of basic science as much as cancer treatment does. Prevention also requires that the basic bench sciences -- genetics, biochemistry and molecular biology -- be integrated with the sciences of prevention: epidemiology and population sciences. Our training program, based in CPPS, builds on Roswell Park's strengths: an established history of multidisciplinary collaboration; a strong group of mentors with numerous funded research projects; and collaboration with the University at Buffalo. The requested revision will use the infrastructure of our existing program to equip an additional basic scientist with the principles, methods and practices needed for cancer prevention research. Our comprehensive training program encourages and supports innovative transdisciplinary research and professional development. The proposed revision will meet the Recovery Act objectives of job creation and accelerating the pace of scientific research by employing a postdoctoral fellow for two years and by training that fellow to launch an independent research career.

描述（由申请人提供）：本提案是为了响应NOT-OD-09-058而提交的，标题为“NIH宣布恢复法案资金可用于竞争性修订申请”。“我们建议扩大我们的NCI R25 T资助的预防博士后培训计划，增加一名能够在两年内完成该计划的受训人员。我们的计划现在是在四个博士后研究员的全部能力;三个是人口科学家，一个是基础科学家。第五名受训人员将是一名基础科学家，他/她可以利用他/她在化学预防和生物标志物领域的专业知识和联系，同时发展行为，营养和/或社会科学方面的研究技能。 我们在罗斯威尔公园癌症研究所（RPCI）的癌症预防的愿景是从扩展转化研究的“实验室到床边”范式。在癌症预防和人口科学（CPPS）高级副总裁James马歇尔博士的领导下，它已扩展为“长凳到人行道”模式，整合了基础长凳，临床，流行病学和人口科学。在这个愿景中，预防需要基础科学的翻译，就像癌症治疗一样。预防还需要将基础科学-遗传学、生物化学和分子生物学-与预防科学-流行病学和人口科学相结合。 我们的培训计划，基于CPPS，建立在罗斯韦尔公园的优势：多学科合作的历史;一个强大的导师与众多资助的研究项目组;并与布法罗大学的合作。所要求的修订将利用我们现有计划的基础设施，为额外的基础科学家提供癌症预防研究所需的原则，方法和实践。我们全面的培训计划鼓励和支持创新的跨学科研究和专业发展。 拟议的修订将满足《复苏法》创造就业机会和加快科学研究步伐的目标，方法是雇用一名博士后研究员两年，并培训该研究员开始独立的研究生涯。