NEUROLOGIC ONCOLOGY

神经肿瘤学项目由来自9个不同部门的22名成员组成， 代表脑肿瘤起源和分子基础的基础实验室研究，神经肿瘤学家， 采取团队方法改善脑癌的放射科医生和神经外科医生 治疗，以及致力于脑癌流行病学的人口科学家。研究目标包括 了解脑癌与神经干细胞的关系，脑肿瘤与神经干细胞的关系 间质环境及其血管系统，以及对改变的信号通路的更好理解。这些 新的见解正在转化为脑癌患者的改进治疗方法，以及 检测肿瘤和药物输送的创新方法。这组调查人员都高度重视 富有成效和互动性。他们的出版物包括发表在《自然》、《癌细胞》、《自然细胞》上的作品 生物学、自然遗传学、新英格兰医学杂志、临床肿瘤学杂志和自然 医学。广泛的出版物涵盖人口科学，细胞信号，基因组学，成像， 和临床科学，以及计划内和计划间出版物的高比例，是 战略整合、高度互动、多样化和富有成效的计划的结果，该计划继续 在实现其既定目标方面取得重大进展。该计划的同行评审支持总额为8,795,681美元 在上一个预算年度。该计划有33%的计划内计划和38%的计划间计划 出版物。

The Neurologic Oncology Program comprises 22 members, drawn from 9 different departments, representing fundamental laboratory research in the origins and molecular basis of brain tumors, neurooncologists, radiologists and neurosurgeons who take a team approach to the improvement of brain cancer therapy, and population scientists working on brain cancer epidemiology. Research goals include understanding how brain cancers relate to neural stem cells, the relationship between brain tumors and their stromal environment and their vasculature, and a better understanding of altered signaling pathways. These new insights are being translated into improved therapies for patients suffering from brain cancer, along with innovative methods of detecting tumors and of drug delivery. This group of investigators is both highly productive and interactive. Their publications include works published in Nature, Cancer Cell, Nature Cell Biology, Nature Genetics, New England Journal of Medicine, Journal of Clinical Oncology, and Nature Medicine. The broad range of publications covering population science, cell signaling, genomics, imaging, and clinical science, as well as the high percentage of intra- and inter-programmatic publications, are the result of a strategically integrated, highly interactive, diverse, and productive Program that continues to make significant progress in reaching its stated goals. The Program has $8,795,681 Total peer reviewed support for the last budget year. The Program has 33% intra-programmatic and 38% inter-programmatic publications.