Human Tissue Acquisition & Pathology Resource

但前提是。 人类组织获取和病理学(HTAP)资源自1989年以来一直在运行。这个 组织库功能始于我们的成人附属医院，收集了各种良性和恶性的 数以千计的样本中的组织。后来的补充增加了我们在肿瘤方面的专业知识 一般银行业，包括前列腺癌(前列腺癌孢子)、乳腺癌(乳房孢子)和 儿童肿瘤(儿科肿瘤学计划)。 该资源在所有主要的教学医院都有高级病理学家，包括圣卢克圣公会 医院、德克萨斯儿童医院、本·陶布综合医院和迈克尔·E·德巴基退伍军人 行政医疗中心。获取组织并将其快速冷冻在冰冻切片区域/手术中 确保RNA完整性的空间。所有样本均附有临床和病理索引和注释 参数。服务(组织处理、切片、特殊染色、免疫组织化学)也是 如果是这样的话。近年来，我们已经创建了组织微阵列并产生了高分辨率图像(Bliss 系统)的虚拟幻灯片。我们已经安排了1700多名患者，超过12000个核心。我们的 随着自动DAKO的加入，免疫组织化学的能力已经得到了扩展 免疫染色剂。我们还提供激光捕获显微解剖(像素II)，费用合理。我们是 目前正在开发自动图像分析能力以及一个基于Web的数据库，该数据库将 所有BCMCC研究人员都可以访问。 所有对服务/组织的请求都提交给资源分配委员会(RAC)进行评估。在……里面 作为批准的一部分，与统计学家一起对拟议的研究进行了权力分析 进程。该资源由医学博士托马斯·惠勒和医学硕士帕梅拉·尤尼斯领导。

PROVIDED. The Human Tissue Acquisition and Pathology (HTAP) Resource has been in operation since 1989. The tissue banking function began at our adult affiliated hospitals and collected a variety of benign and malignant tissues that number in the thousands of specimens. Later additions have increased our expertise in tumor banking generally, to include prostate cancer (Prostate SPORE), breast cancer (Breast SPORE), and childhood tumors (Pediatric Oncology Program). The Resource has senior pathologists at all major teaching hospitals, including St. Luke's Episcopal Hospital, Texas Children's Hospital, Ben Taub General Hospital, and the Michael E. DeBakey Veterans Administration Medical Center. Tissue is procured and snap-frozen in the frozen section area/operating room to ensure RNA integrity. All samples are indexed and annotated with clinical and pathological parameters. Services (tissue processing, sectioning, special stains, immunohistochemistry) are also provided. In recent years we have created tissue microarrays and produced high-resolution images (Bliss system) of a virtual slide. We have arrayed over 1700 patients with over 12,000 cores. Our immunohistochemistry capabilities have been expanded with the addition of an automated DAKO immunostainer. We also offer Laser Capture microdissection (PIXEL II) for a reasonable fee. We are currently developing automated image analysis capabilities as well as a web-based data bank that will be accessible to all BCMCC researchers. All requests for services/tissue are submitted to the Resource Allocation Committee (RAC) for evaluation. In conjunction with a statistician, a power analysis is done for the proposed study as part of the approval process. The Resource is led by Thomas Wheeler, M.D., and Pamela Younes, M.S.