PROG 9- Cancer Epidemiology

癌症流行病学计划(CEP)的目标是提高我们预防癌症和 通过在监测、病因、护理模式和生存方面的新知识，使用 跨学科的方法。特别强调种族、民族、文化和其他群体 与癌症的负担不同。这项研究主要是通过大规模人口调查进行的 旧金山湾区不同种族人群的病例对照和队列研究， 包括奥克兰和圣何塞。病例对照研究通常收集人口统计学和接触情况 数据、外周淋巴细胞DNA和/或存档的肿瘤样本。队列研究的基础是 对健康个体的癌症发病率的跟踪(例如，加州教师研究)，以及事件 癌症护理、生活质量和生存的案例(例如，CANCORS和家庭登记处)。癌症部位 特别感兴趣的包括乳腺癌、卵巢癌、前列腺癌和淋巴瘤。这项工作得到了便利， 最近斯坦福大学和北加州大学之间的正式合作得到了加强 癌症中心(NCCC)。项目研究的一些亮点包括口服避孕药的发现 在携带者中，使用药物与降低卵巢癌风险和不增加乳腺癌风险相关 在BRCA1突变中，幽门螺杆菌感染与食道风险降低相关 癌症，在使用替代癌症治疗方法方面存在种族差异，以及选择保乳 手术与社会经济地位、移民身份和文化适应有关，以及 种族/民族。该计划通过其基于人群的研究为癌症中心增加价值 为发展重要的跨学科协作提供坚实基础的资源 进行翻译研究。爱丽丝·S·惠特莫尔博士和埃斯特·M·约翰博士是该项目的负责人， 两位资深癌症流行病学家都有广泛的癌症研究计划，他们曾在一起工作 已经超过15年了。CEP由23名成员组成，直接成本资金为20 220 819美元，包括 6,463,763美元的NCI资金。从2000年到现在，出版物的平均数量 按方案成员分列的是每年33个；其中40%是方案内方案，14%是方案间方案。 未来计划包括扩大方案内和方案间的互动 调查人员，确定新的研究机会，并评估数据收集的可行性 癌症中心内的共享资源。

The goal of the Cancer Epidemiology Program (CEP) is to improve our ability to prevent cancer and reduce its burden through new knowledge in surveillance, etiology, patterns of care, and survival, using an interdisciplinary approach. Special emphasis is placed on racial, ethnic, cultural, and other groups with an unequal burden of cancer. This research has been conducted primarily via large populationbased case-control and cohort studies in the ethnically diverse population of the San Francisco Bay Area, which includes Oakland and San Jose. Case-control studies typically collect demographic and exposure data, DNA from peripheral lymphocytes, and/or archived tumor samples. Cohort studies are based on follow-up of healthy individuals for cancer incidence (e.g., California Teachers Study), and of incident cases for cancer care, quality of life, and survival (e.g., CanCORS and Family Registries). Cancer sites of particular interest include breast, ovary, prostate, and lymphomas. This work has been facilitated and enhanced by the recent formal affiliation between Stanford University and the Northern California Cancer Center (NCCC). Some highlights of Program research include findings that oral contraceptive use is associated with reduced ovarian cancer risk and no elevation in breast cancer risk among carriers of BRCA1 mutations, that Helicobacter pylori infection is associated with reduced risk of esophageal cancer, that ethnic differences exist in use of alternative cancer therapies, and that choice of breastconserving surgery is related to socioeconomic status, immigration status and acculturation, and race/ethnicity. The Program adds value to the Cancer Center through its population-based study resources that provide a strong basis for developing important interdisciplinary collaborations and conducting translational research. Dr. Alice S. Whittemore and Dr. Esther M. John lead the Program, both senior cancer epidemiologists with extensive cancer research programs who have worked together for over 15 years. The CEP consists of 23 members, with direct cost funding of $20,220,819, including $6,463,763 in NCI funding. In the period from 2000 to the present, the average number of publications by Program members was 33 per year; of these, 40% were intra-programmatic and 14% were interprogrammatic. Future plans include expanding intra- and inter-programmatic interactions among investigators, identifying new research opportunities, and evaluating the feasibility of a data collection Shared Resource within the Cancer Center.