CELLULAR HOMOLOGS IN A NEW SIMIAN HERPESVIRUS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。艾滋病相关卡波西肉瘤(KS)是艾滋病相关的主要恶性肿瘤。人们认为，逆转录病毒HIV和疱疹病毒Kaposi肉瘤相关疱疹病毒(KSHV)之间的相互作用导致了疾病的发病。KSHV感染和KSHV相关恶性肿瘤是新出现的疾病，流行于地中海和撒哈拉以南非洲，但正在蔓延到美国和欧洲。SRV-2相关性腹膜后纤维瘤病(RF)与KSHV样疱疹病毒RFHVMn相关，是了解逆转录病毒和疱疹病毒在诱导肿瘤发生中相互作用的独特动物模型。了解这种动物模型中的病毒传播和肿瘤启动将提供关于人类和猕猴疾病的独特信息，这是开发KS治疗方法的基本前提。在这个项目中，我们建议建立猕猴RFHV感染周期的基线参数。为了确定这种病毒是否在腹膜后纤维瘤病(RF)的发展中起作用，我们将描述它的感染周期以及SRV-2和其他免疫抑制剂对这些周期的干扰。我们将研究病毒传播和宿主对感染的反应。研究人群将包括感染RFHV的猕猴，包括活跃的、潜伏的或实验性感染的猕猴。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIDS-related Kaposi's sarcoma (KS) is the major AIDS-related malignancy. It is believed that an interaction between the retrovirus, HIV, and the herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV), results in disease pathogenesis. KSHV-infection and KSHV-related malignancies are newly emerging diseases which are prevalent in the Mediterranean and Sub-Saharan Africa but are spreading into the U.S. and Europe. It is believed that SRV-2 related retroperitoneal fibromatosis (RF) which is associated with the KSHV-like herpesvirus, RFHVMn, is a unique animal model for understanding the interactions of retroviruses and herpesviruses in the induction of tumorigenesis. Understanding virus transmission and tumor initiation in this animal model would provide unique information concerning both the human and macaque diseases which is an essential prerequisite to developing treatments for KS. In this project, we propose to establish the baseline parameters of the infectious cycle of the macaque RFHV. To determine if this virus plays a role in the development of retroperitoneal fibromatosis (RF) we will characterize its infectious cycles and the perturbation of these cycles by SRV-2 and other immunosuppressive agents. We will study virus transmission and the host response to infection. Study populations will include macaques with either active, latent or experimental infections with RFHV.