CASPASE 8 AND AUTOPHAGY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。FADD-caspase-8复合物是许多细胞诱导凋亡的途径。令人费解的是，在抗原诱导活化条件下，FADD和caspase-8都是T淋巴细胞存活所必需的。B细胞通过toll相关受体（tlr）激活是不同的，但抗原受体不依赖于FADD和caspase-8。在缺乏caspase-8的情况下，T细胞会发生自噬，我们有兴趣确定B细胞是否也是如此。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The FADD-caspase-8 complex constitutes a pathway to induced apoptosis in many cells. Enigmatically, both FADD and caspase-8 are necessary for T lymphocyte survival under conditions of antigen-induced activation. B cells are different in that activation through Toll-related receptors (TLRs), but not antigen receptors is FADD and caspase-8 dependent. In the absence of caspase-8 T cells undergo autophagy, and we are interested to determine whether the same is true for B cells.