NEURONAL REMODELING AFTER RETINAL DETACHMENT AND DURING RECOVERY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们将使用已建立的视网膜脱离和再附着动物模型来研究光感受器突触和神经元的重塑。这种神经元重塑可能是成功再植手术后视力不完全恢复的机制基础。这些信息与了解视网膜对创伤反应的基本机制有关，也可能为其他致盲疾病的治疗提供线索。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We will use an established animal model of retinal detachment and reattachment to sutdy the remodeling of photoreceptor synapses and neurons. This neuronal remodeling may underlie the mechanisms for the imperfect recovery of visiion that often occurs after successful reattachment srugery. The information is relevant to undertanding the fundamental mechanisms underlying the retina¿s reaction to trauma and it may also hold clues to therapies for other blinding disorders.