RETINAL CELL REMODELING UTILIZING ADVANCED IMAGING TECHNOLOGY

利用先进成像技术重塑视网膜细胞

• 批准号: 8361929
• 负责人: Steven A. Fisher
• 金额: $ 3.7万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361929
• 关键词: Biological Assay; Cells; Cellular biology; Collaborations; Family Felidae; Funding; Goals; Grant; Image Analysis; Imaging technology; National Center for Research Resources; Photoreceptors; Presynaptic Terminals; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Retina; Retinal; Retinal Detachment; Series; Source; Synaptic plasticity; Tissues; United States National Institutes of Health; cost; electron tomography; image processing; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project represents a series of related collaborative projects on retina cell biology. Our overall goal is to provide reconstructed volumes of retinal tissue, emphasizing photoreceptor synaptic terminals in a novel study of photoreceptor synaptic plasticity. Our collaboration with the NCMIR researchers will use their advanced electron tomography resources and image processing schema to assay the structural correlates of changes in feline photoreceptor synaptic terminals after retinal detachment and reattachment.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 该项目代表了视网膜细胞生物学方面的一系列相关合作项目。我们的总体目标是提供重建体积的视网膜组织，在一项关于光感受器突触可塑性的新研究中强调光感受器突触终末。我们与NCMIR研究人员的合作将使用他们先进的电子断层扫描资源和图像处理模式来分析视网膜脱离和复位后猫科动物光感受器突触终末变化的结构相关性。