BRAIN PERFUSION IMAGING & FUNCTIONAL STUDIES: HIV NEUROCOGNITIVE IMPAIRMENT

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究集中在新的灌注和脑功能成像技术的生物医学应用的发展。本项目的总体目标是继续开发用于临床应用的动脉自旋标记（ASL）灌注MRI，包括成人和儿童卒中、外周血管疾病和功能性脑标测。 在子项目0008、0053和0061中，最近优化的动脉自旋标记（ASL）灌注技术用于评价HIV相关神经认知损害对尾状核血流量和血容量的影响。 尾状核血流量和血容量的下降趋势与HIV相关神经认知障碍（HNCI）的显著增加相关，在受损更严重的患者中观察到最大的下降。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study concentrates on the development of new perfusion and brain functional imaging techniques for biomedical applications. The overall goal of this project is continued development arterial spin labeled (ASL) perfusion MRI for use in clinical applications including adult and pediatric stroke, peripheral vascular disease, and functional brain mapping. Recently optimized arterial spin labeled (ASL) perfusion technique in subprojects 0008, 0053 and 0061 is used to evaluate the effects of HIV-associated neurocognitive impairment on caudate blood flow and volume. Decreasing trends in caudate blood flow and volume were associated with significantly increasing HIV-associated neurocognitive impairment (HNCI), with the greatest decreases observed for more severely impaired patients.