PROTEIN SYNTHESIS AS RELATED TO LONG TERM MEMORY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。人们早就知道，蛋白质合成是联想学习巩固到长期记忆中所必需的。在我们最近在MBL的工作中，我们能够证明，在训练前几天激活PKC同工酶可以诱导合成后续长期记忆(LTM)巩固所必需的和充分的蛋白质。我们相信，这项工作，再加上与生物化学相一致的相关电生理学，是我们在理解长期记忆如何存储在大脑中的重要一步。考虑到我们目前实验中使用的关键药物bryostatin即将进入临床试验，这些发现再次说明了海洋模型在揭示大脑功能的基本原理方面的力量--特别是当它们与人类有关时。我们已经利用BRC的资源来探索潜在的电生理机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Protein synthesis has long been known to be required for associative learning to consolidate into long-term memory. In our recent work at the MBL, we were able to demonstrate that PKC isozyme activation on days before training can induce the synthesis of proteins necessary and sufficient for subsequent long-term memory (LTM) consolidation. We believe that this work, coupled with correlative electrophysiology that is consistent with the biochemistry, is a major step forward in our understanding of how long-term memory is stored in brains. Considering that the key drug used for our current experiments, bryostatin, is about to go into clinical trials, these findings once more illustrate the power of marine models for uncovering fundamental principles of brain function - particularly as they relate to man. We have used the resources of the BRC to pursue the underlying electrophysiological mechanisms.