NEURONAL GLUCOSE DETECTION & HYPOGLYCEMIA-ASSOCIATED AUTONOMIC FAILURE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。强化胰岛素治疗是预防所有1型糖尿病患者和许多2型糖尿病患者高血糖引起的损害的唯一途径。然而，胰岛素治疗会产生危及生命的副作用：低血糖。此外，即使是低血糖发作，大脑也无法检测到未来的低血糖发作。这种综合征统称为低血糖相关性自主神经衰竭（HAAF）和低血糖无意识症，可使血糖水平在没有检测到的情况下下降到严重甚至致命的水平。我们的目标是了解在反复低血糖导致HAAF时，大脑感知葡萄糖的能力是如何受损的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Intensive insulin therapy is the only way to prevent hyperglycemia-induced damage in all patients with Type I, and many with Type 2, Diabetes Mellitus. However, insulin therapy produces a life-threatening side effect ¿ hypoglycemia. Moreover, even on bout of hypoglycemia renders the brain unable to detect future hypoglycemia episodes. This syndrome, known collectively as hypoglycemia-associated autonomic failure (HAAF) and hypoglycemia unawareness, allows blood glucose levels to fall to severe, even lethal, levels without detection. It is our goal to understand how the brain¿s ability to sense glucose becomes impaired during recurrent hypoglycemia leading to HAAF.