ASSOCIATION OF THE ESTROGEN RECEPTOR WITH NUCLEAR PROTEINS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。雌激素受体(ER)与激素和雌激素反应元件(ERE)结合，启动雌激素反应基因的转录。然而，已经很清楚的是，内质网并不是孤立地发挥作用，而是需要许多共同调节蛋白的参与。我们感兴趣的是识别与DNA结合的ER相互作用的新的共调节蛋白，以及确定ERE序列是否改变了蛋白质与ERE结合受体的联系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Binding of the estrogen receptor (ER) to hormone and the estrogen response element (ERE) initiates transcription of estrogen responsive genes. However, it has become clear that the ER does not act in isolation but requires the participation of numerous coregulatory proteins. We are interested in identifying novel coregulatory proteins that interact with the DNA-bound ER and in determining whether the ERE sequence alters the association of proteins with the ERE-bound receptor.